CAS: 17673-25-5; (1Ar,1Bs,4Ar,7As,7Bs,8R,9R,9As)-4A,7B,9,9A-Tetrahydroxy-3-(Hydroxymethyl)-1,1,6,8-Tetramethyl-1B,4,4A,7A,7B,8,9,9A-Octahydro-1H-Cyclopropa[3,4]Benzo[1,2-E]Azulen-5(1Ah)-One

上下游产品

CAS号20839-06-9 佛波醇-12-单吡啶 | CAS号20839-16-1 (1aR,1bS,4aR,7a... | CAS号19891-06-6 Phorbol-12,13,2... | CAS号24928-15-2 12,13-二乙酸佛波醇 | CAS号16561-29-8 12-O-十四烷酰佛波醋酸酯-13 | CAS号83920-66-5 12-O-n-Hexanoyl... | CAS号41621-85-6 佛波醇-13,20-二乙酸酯

📜[(1S,6S,8R,9R,10R,11R,13S,15S)-9-[tert-Butyl(Dimethyl)Silyl]Oxy-8,12,12,15-Tetramethyl-4,14-Dioxo-1,6-Bis(Trimethylsilyloxy)-13-Tetracyclo[8.5.0.02,6.011,13]Pentadec-2-Enyl] Acetate置于3,5-二甲基吡唑,Chromium(Vi) Oxide,4-二甲氨基吡啶,Selenium(Iv) Oxide,Sodium Tetrahydroborate,Copper(L) Iodide,二(氰基苯)二氯化钯,双[α,α-双(三氟甲基)苯甲醇合]二苯硫,三苯胂,叠氮基三甲基硅烷,四丁基氟化铵,三乙酰氧基硼氢化钠,Sodium Cyanoborohydride,氟化氢吡啶,溶剂黄146,Barium(II) Hydroxide体系中,用 四氢呋喃,N-甲基吡咯烷酮,甲醇,二氯甲烷,1,2-二氯乙烷,苯 用作溶剂,化学反应生成4Beta,9Alpha,12Beta,13Alpha,20-五羟基惕各-1,6-二烯-3-酮
参考文献:(+)-佛波醇的十九步全合成
标题:(+)-佛波醇的十九步全合成
摘要:佛波醇是蒂利亚烷二萜家族的旗舰成员,已为人所知 80 多年,并因其引人入胜的化学结构和佛波醇酯的药用潜力而引起了众多化学家和生物学家的关注.获得有用数量的佛波醇和相关类似物依赖于从天然来源和半合成中分离出来.尽管进行了 40 年的努力,但由于化学合成的复杂性和氧原子的不寻常位置,化学合成一直无法与这些策略竞争.纯合成的对映体纯佛波醇仍然难以捉摸,生物合成甚至没有导致这个萜烯家族中最简单的成员.最近,Eudesmanes,Germacrenes,紫杉烷类和原原单烯类都受益于受两相萜烯生物合成逻辑启发的策略,其中强大的 C-C 键构建和 C-H 键氧化齐头并进.在这里,我们实施了一种两相萜烯合成策略,只需 19 步即可从丰富的单萜 (+)-3-Carene 中实现 (+)-佛波醇的对映特异性全合成.这种合成路线的目的不是取代分离或半合成作为产生天然产物本身的一种手段,而是能够获得含有独特氧
Doi:10.1038/nature17153

专利信息

专利号:US-7041479-B2
优先权日:2000-09-06
标题 :Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:TRUSTESS OF THE LELAND STANFOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-2012130699-A1
优先权日:2010-11-22
标 题 :Method of molecular design and synthesis of therapeutic and preventive drugs
发明人：MARTYNOV ARTUR; FARBER BORIS S; FARBER SONYA SOPHYA
权利人:MARTYNOV ARTUR; FARBER BORIS S; FARBER SONYA SOPHYA
摘要:Industrial Application: This invention may be used in human and veterinary medicine for the design (creation and synthesis) of therapeutic and preventive drugs that are effective for the treatment of oncological and viral human and animal illnesses and for the design of new medicines. n Summary of the Invention: A new method of design and synthesis of therapeutic and preventive drugs in which a biopolymer target (protein, DNA, RNA, or a mixture of these) is used, and in the capacity of a ligand, the same biopolymer target is used, which is cut into oligomer fragments (nucleases, synthetic nucleases, and proteases); the fragments are modified through changing their charges to the opposite charge (acylation of anhydrides of dicarbonate acids or alkylation with halogen-carbonic acids). Also in the capacity of a ligand, the same biopolymer target is used, which is modified by partially changing the molecules' charges to the opposite with the creation of supramolecular biopolymer assemblies. We used supramolecule assemblies made from oligomers that were products of the hydrolysis of biopolymers, but with a change of the charge of the molecules to the opposite charge, as well as the partial change of the charges of the target biopolymers. n Technical Result: A method of molecular design and synthesis of new, unique therapeutic and preventive drugs based on self-organizing systems. The application of the method will allow a significant cut to expenditures on the design and synthesis of new drugs, expand the activity spectra of existing protein gene-engineered drugs, and create new classes of dynamic therapeutic and preventive drugs that self-adapt to the organism and target.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-2014220556-A1
优先权日:2013-02-06
标题 :Method of Design and Synthesis of a New Drug
发明人：MARTYNOV ARTUR; FARBER BORIS S; FARBER SONYA SOPHYA
权利人:MARTYNOV ARTUR; FARBER BORIS S; FARBER SONYA SOPHYA
摘要:A method of design and synthesis of a new drug. This invention may be used in human and veterinary medicine for the design of new drugs that are effective in the treatment of oncological and viral human and animal illnesses and for the design of new medicines. In the method a biopolymer target for the drug action is selected; then the quantity of nitrogen-containing positively charged groups available for modification is calculated. Biopolymer target may be cut into oligomer fragments. Some of calculated nitrogen-containing positively charged groups are substituted with negatively charged groups by combinatorial modification. The obtained supramolecular assemblies are used as drug for the biopolymer target.

专利号:US-7384739-B2
优先权日:2001-11-14
标题 :Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof
发明人：KITABAYASHI MASAO; KUROITA TOSHIHIRO; ISHIDA YOSHIKAZU; KOMATSUBARA HIDEYUKI; NISHIYA YOSHIAKI; OKA MASANORI; KAWAMURA YOSHIHISA; IMANAKA TADAYUKI
权利人:TOYO BOSEKI
摘要:The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA synthesis reactions. The invention further provides a thermostable DNA polymerase-related factor derived from Thermococcus species, which has an activity to promote the DNA synthesis activity of DNA polymerase or which binds to DNA polymerase.

专利号:WO-9614060-A1
优先权日:1994-11-04
标题 :Use of receptor agonists to stimulate superoxide dismutase activity
发明人：MARKLUND STEFAN L; STRAALIN PONTUS
权利人:MARKLUND STEFAN L; STRAALIN PONTUS
摘要:The present invention relates to the use of a substance for the manufacture of a composition for stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells. In particular, the invention relates to the use of a substance for the manufacture of a composition for prophylaxis or treatment of a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical. Further, the invention relates to a method for determining the effect of a substance with respect to stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells and to substances which have been selected by said method. Within the scope of the invention is a method of preventing, diminishing, controlling or inhibiting a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical in a patient who has been established to have a high risk of developing a such disease or disorder, or who has developed a such disease or disorder, the method comprising administering an effective amount of a substance which is capable of stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells.