CAS: 17407-37-3; Vitamin E Succinate

上下游产品

Dl-α-生育酚 Vitamin E 10191-41-0
天然维生素e Tocopherol 59-02-9

📜异植物醇置于三乙胺,Zinc(II) Chloride体系中,用 乙酸丁酯,甲苯 用作溶剂,20.0~129.0 °C,300.01 Kpa 条件下,反应 6.0H,反应生成生育酚琥珀酸酯
参考文献:一种高纯度生育酚琥珀酸酯盐的制备方法
标题:一种高纯度生育酚琥珀酸酯盐的制备方法
摘要:本发明涉及有机合成领域,特别是涉及一种生育酚琥珀酸酯盐的制备方法.本发明提供一种生育酚琥珀酸酯盐的制备方法,包括:将dl‑α‑生育酚在贵金属催化剂存在的条件下进行氢化,将氢化所得产物与琥珀酸酐在碱存在的条件下进行酯化反应制备获得生育酚琥珀酸酯中间体;将所述生育酚琥珀酸酯中间体成盐.本发明所提供的生育酚琥珀酸酯盐的制备方法能够有效提升目标产品的纯度,并能够有效降低单一杂质的含量,所制备获得的钙盐产品纯度可达到99.9%以上.

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).