CAS: 15879-93-3; Chloralose

结构式图片

欧盟法规

统一分类与标签ECHA物质ECHA物质工作场所安全标识要求C&L通报欧盟生物杀灭剂法规欧盟《生物杀灭剂法规》REACH预注册废弃物危险特性清单

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CAS号302-17-0 水合氯醛 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号104-15-4 对甲苯磺酸 | CAS号75-87-6 三氯乙醛 | CAS号39598-39-5 (S)-1,2-O-trich... | CAS号7664-93-9 硫酸 | CAS号498-07-7 1,6-脱水-β-D-葡萄糖

合成工艺路线路线简述

  • 合成目标产物 α-Chloralose 主要起始原料 D(+)-Glucose And P-Toluenesulfonic Acid And Chloral
  • (文献来源)合成步骤主要原料 D(+)-Glucose 和 P-Toluenesulfonic Acid 和 Chloral
α-Chloralose置于吡啶,甲醇,Sodium Methylate体系中,化学反应生成Alpha-氯醛糖
参考文献:Glucofuranose Derivatives As A Library For Designing And Investigating Low Molecular Mass Organogelators
标题:Glucofuranose Derivatives As A Library For Designing And Investigating Low Molecular Mass Organogelators
摘要:We Designed And Synthesized A Class Of Saccharide-Based Gelators Having Three Free Oh Groups In The Glucofuranose Fragment. The Gelating Abilities Of Fourteen Compounds Were Examined To Systematically Study The Influence Of The Hydrophobic Fragment Connected To The C2' Carbon. Also The Correlation Between The Saccharide Crystal Structure And Its Gelating Properties Was Examined,Showing Limited Usefulness In This Particular Case. Sem Observations Were Carried Out In Order To Investigate The Hierarchical Structure Of Xerogels And Changes Depending On Different Gel Concentration. (C) 2005 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2005.07.093

海关参考信息

专利信息


专利号:US-6486169-B1
优先权日:2002-02-19
标题:Botanical drug for treatment and prevention of alzhimer's disease
发明人:LIU YAGUANG
摘要:The present invention related to safe botanical drug for treatment and prevention of Alzheimer's disease. Specifically, this invention proves a safe botanical drug, Huperzine (HUE) and Clausenamide (CLE) and their preparation.HUE has the following pharmaceutical functions: inhibiting acetylcholinesterase (CAT), increasing memory, decreasing Alzheimer amyloid protein, increasing RNA and protein synthesis of brain, increasing calcium in brain, decreasing superoxide anion.CLE has the following pharmaceutical functions: increasing memory, decreasing Alzheimer amyloid protein, increasing RNA and protein synthesis of brain, increasing calcium in brain, decreasing superoxide anion, increasing long-term potentiation and increasing dopanmine (DA). It is important that HUE combined with CLE have stronger function as mentioned above.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:WO-2021074309-A1
优先权日:2019-10-16
标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

专利号:WO-2021074311-A1
优先权日:2019-10-16
标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

专利号:US-4190658-A
优先权日:1977-07-25
标 题 :14-Imino-(15H)-eburnamine compounds, compositions, methods of use and process of synthesis
发明人:FARCILLI ANDRE; MEDICI ITALO; WARNANT JULIEN
权利人:ROUSSEL UCLAF
摘要:Novel eburnamenine derivatives of the formula I in the form of racemic mixtures or optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts which are oxygenators and cerebral vasoregulators of great value.

专利号:EP-0001021-B1
优先权日:1977-07-25
标 题 :Derivatives of pentacyclic alcaloids, method for their preparation, application in the synthesis of products of the eburnamonine group and pharmaceutical compositions
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1: Shen B, Wang J, Tai C, Beckel JM. Facilitation of non-nociceptive bladder activity and suppression of somatic afferent inhibition by hypogastric afferents in cats. Front Neurosci. 2025 Feb 20;19:1555152. doi: 10.3389/fnins.2025.1555152.
2: Yuan Y, Liu T, Wang J. Enhancing anesthetic techniques for improving whisker stimulation response in the barrel cortex. PLoS One. 2025 Feb 25;20(2):e0318306. doi: 10.1371/journal.pone.0318306.
129:107551. doi: 10.1016/j.vascn.2024.107551. Epub 2024 Sep 7. 602(16):4027-4052. doi: 10.1113/JP286680. Epub 2024 Jul 19.

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参考文献:10.1126/science.1205216
摘要:Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science. 2011 Aug 05;333(6043):724–9.
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