CAS: 13813-19-9; Sulfuric Acid-D2

该化合物是硫酸的离子化形式,氢原子被除化铀(D)所取代.这种同位素标签化合物在NMR光谱中广泛用作溶剂或酸介质,由于没有质子干扰而提高了信号分辨率.其非交换性原子使有机和无机化学的机械研究,特别是酸催化反应的机械研究很有价值.硫酸D2还用于动力同位素效果调查和代谢研究中的追踪器.该化合物保持硫酸的强酸特性,同时提供同位素纯度,确保敏感分析应用的可靠结果.

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CAS号7446-11-9 三氧化硫 | CAS号7789-20-0 重水 | CAS号19029-50-6 高氯酸溶液-D | CAS号7789-20-0 重水 | CAS号758-12-3 乙酸-D{1} | CAS号7698-05-7 氘代盐酸 | CAS号13587-52-5 硝酸-d | CAS号13762-18-0 Dihydrogen sulf... | CAS号7783-06-4 硫化氢 | CAS号13536-94-2 硫化氘 | CAS号29171-24-2 DEUTEROFLUOROSU... | CAS号3017-23-0 Hydr°Cyanic acid-d

合成工艺路线路线简述

    三氧化硫,重水 反应生成氘代硫酸
    参考文献:三氰甲烷的存在
    标题:三氰甲烷的存在
    摘要:三氰氨化钙与氟化氢反应生成三氰基甲烷和ca(hf 2)2.三氰甲烷在−40oc以下稳定,并通过ir,拉曼和NMR光谱进行了表征.振动光谱进行比较,以在理论的pbe1Pbe / 6-311G(3Df,3Dp)水平的量子化学的频率和确认所述预测ç 3 V与常规的c分子的对称性 H(109.8分),C ç (146.7 Pm)和cn(114.7 Pm)债券.
    Doi:10.1002/anie.201506753

    专利信息


    专利号:US-9315483-B2
    优先权日:2007-09-13
    标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
    发明人:JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
    权利人:CONCERT PHARMACEUTICALS INC
    摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

    专利号:US-7652172-B2
    优先权日:2004-09-20
    标题:Expeditious synthesis of DPD
    发明人:SEMMELHACK MARTIN F; CAMPAGNA SHAWN R; BASSLER BONNIE L; FEDERLE MICHAEL J
    权利人:UNIV PRINCETON
    摘要:This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.

    专利号:US-2024309003-A1
    优先权日:2021-05-04
    标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
    发明人:HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
    权利人:VIGIL NEUROSCIENCE INC
    摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

    专利号:US-2009234121-A1
    优先权日:2008-01-16
    标 题 :Tridentate (nnc) catalysts for the selective oxidation of hydrocarbons
    发明人:PERIANA ROY A; GODDARD III WILLIAM A; OXGAARD JONAS; YOUNG KENNETH
    权利人:PERIANA ROY A; GODDARD III WILLIAM A; OXGAARD JONAS; YOUNG KENNETH
    摘要:The synthesis of discrete, air, protic, and thermally stable transition metal NNC complexes that catalyze the CH activation and functionalization of alkanes and arenes is disclosed. Methods for the selective conversion of methane to methanol or methyl esters in acidic and neutral media are disclosed.

    专利号:US-2024286990-A1
    优先权日:2021-06-18
    标题:Vinylated keto esters with applicability in signal enhanced magnetic resonance imaging and synthesis thereof
    发明人:GLÖGGLER STEFAN; KORCHAK SERGEY; JAGTAP ANIL P; SAUL PHILIP; MOLL DENIS
    权利人:MAX PLANCK GESELLSCHAFT
    摘要:The present invention relates to a vinyl keto ester and intermediates of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediates is partly or fully deuterated. Furthermore, the present invention relates to two alternative methods of preparing said vinyl keto ester. The first method is a multi-step approach comprising the steps of providing a carboxylic acid that comprises a geminal diol moiety protected by a photolabile protecting group, vinylating said carboxylic acid using vinyl acetate, and cleaving the protecting group by applying UV light. The second method is a one-step approach of reacting a carboxylic acid that comprises an additional carbonyl moiety with acetylene in the presence of a metal catalyst. In both methods, the compounds used may be fully or partly deuterated.

    专利号:WO-2009035652-A1
    优先权日:2007-09-13
    标 题 :Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
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    主要参考文献

    参考标题:Substituted Dihydropyridine Synthesis By Dearomatization Of Pyridines
    作者:Arne Heusler,Julian Fliege,Tobias Wagener,Frank Glorius |发布日期:2021.6.14
    摘要:Sensitive Reagents Restricts The Applicability In Synthetic Laboratories. Herein, We Report The Synthesis Of A Broad Variety Of N-Substituted 1,4- And 1,2-Dihydropyridines By Very Mild And Selective Reduction With Amine Borane For The First Time.

    合成参考文献


    摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026).
    参考文献:10.1038/s41563-020-0764-y
    摘要:Knebel A, Bavykina A, Datta SJ, Sundermann L, Garzon-Tovar L, Lebedev Y, Durini S, Ahmad R, Kozlov SM, Shterk G, Karunakaran M, Carja ID, Simic D, Weilert I, Klüppel M, Giese U, Cavallo L, Rueping M, Eddaoudi M, Caro J, Gascon J. Solution processable metal-organic frameworks for mixed matrix membranes using porous liquids. Nat Mater. 2020 Dec;19(12):1346–53. doi: 10.1038/s41563-020-0764-y.
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