CAS: 134-20-3; Methyl Anthranilate

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CAS号606-27-9 2-硝基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号118-48-9 靛红酸酐 | CAS号118-92-3 邻氨基苯甲酸 | CAS号16714-23-1 methyl 2-azidob... | CAS号610-96-8 邻氯苯甲酸甲酯 | CAS号201230-82-2 carbon monoxide | CAS号615-36-1 2-溴苯胺 | CAS号610-94-6 2-溴苯甲酸甲酯 | CAS号5344-90-1 2-氨基苯甲醇 | CAS号107027-12-3 N-[2-(dimethyla... | CAS号105908-32-5 methyl 2,3-dime... | CAS号606-27-9 2-硝基苯甲酸甲酯 | CAS号93-58-3 苯甲酸甲酯 | CAS号6587-24-2 邻氰基苯甲酸甲酯 | CAS号119-36-8 水杨酸甲酯 | CAS号5081-87-8 3-(2-氯乙基)-2,4(1... | CAS号31739-56-7 2-(1H-吡咯)苯甲醛 | CAS号5471-20-5 2-氨基-N-苄基苯甲酰胺 | CAS号31827-04-0 3-羟基-1H-吲哚-2-羧酸甲酯

邻氨基苯甲酸置于氯化亚砜,Potassium Carbonate体系中,化学反应 6.0H,反应生成邻氨基苯甲酸甲酯
参考文献:新型喹唑啉酮酰肼衍生物作为 Egfr 抑制剂的设计,合成和分子对接.
标题:新型喹唑啉酮酰肼衍生物作为 Egfr 抑制剂的设计,合成和分子对接.
摘要:设计并合成了一系列新型喹唑啉酮酰肼衍生物作为egfr抑制剂.结果表明,大多数目标化合物具有潜在的抗肿瘤细胞增殖和egfr抑制活性.在所有受试化合物的综合分析中,目标化合物9C显示出最好的抗肿瘤细胞增殖活性,(mcf-7的ic50 =1.31 μm,Hepg2的ic50 =1.89 μm,Sgc的ic50 =2.10 μm),和egfr 抑制活性的 Ic50 =0.59 μm.对接结果表明,化合物9C可以理想地插入活性位点并与活性位点中的关键氨基酸残基(val702,Lys721,Met769,Asp831)相互作用.
Doi:10.1002/cbdv.202200189

专利信息

专利号:US-7429658-B2
优先权日:2003-09-11
标题 :Synthesis of protected pyrrolobenzodiazepines
发明人：HOWARD PHILIP; MASTERSON LUKE
权利人:SPIROGEN LTD
摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):

专利号:WO-2025073852-A3
优先权日:2023-10-03
标题:Enzymatic synthesis of glycosylated anthranilate derivatives
发明人：HEDEDAM WELNER DITTE; NAHUEL BIDART COSTOYA GONZALO; GHARABLI HANI
权利人:UNIV DANMARKS TEKNISKE
摘要:The present invention concerns enzymatic synthesis of glycosides of anthranilate derivatives, such as methyl anthranilate N-glucoside, ethyl anthranilate N-glucoside, and butyl anthranilate N-glucoside. These anthranilate derivatives may preferably be used as insect and/or bird repellent.

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:WO-2024259491-A1
优先权日:2023-06-23
标 题:New synthesis method
发明人：FORD DANIEL; POZNAKS VIKTORS; FOTINS JURIS; ÄŒERÅ…AKS DMITRIJS
权利人:THE HEART RES INSTITUTE LTD
摘要:The present disclosure generally relates to a process for the synthesis of AZD6482. In particular, the present disclosure also relates to a process for the synthesis of enantiomerically pure AZD6482. The present disclosure also relates to a process for the synthesis of enantiomerically pure intermediates. The present disclosure also relates to compounds prepared by the processes and the use of such compounds to prepare compositions and to treat disorders.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.