CAS: 13027-88-8; 2-Hydroxy-2-Methylpropanamide

相似化合物

2854-16-2 598-81-2 2043-43-8

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丙酮氰醇置于己酰胺,溶剂黄146,Palladium (II) Nitrate体系中,化学反应 0.67H,以94%的收率获得2-羟基异丁酰胺
参考文献:氰醇催化转移水合为 α-羟基酰胺
标题:氰醇催化转移水合为 α-羟基酰胺
摘要:我们报告了通过使用羧酰胺作为水供体,钯 (II) 催化的氰醇转移水合为 α-羟基酰胺.该方法能够在温和条件下(50°C,10 分钟)选择性地水合各种醛和酮衍生的氰醇,分别提供 α-单-和 α,α-二取代-α-羟基酰胺.非诺贝特(一种带有二苯甲酮部分的药物)直接转化为功能化的 α,α-二芳基-α-羟基酰胺是通过氢氰化-转移水合序列实现的.初步动力学研究和位点特异性 18O 标记的 α-羟基酰胺的合成证明了羰基氧从羧酰胺试剂转移到 α-羟基酰胺产物中.
Doi:10.1021/jacs.8B12877

专利信息

专利号:US-6995284-B2
优先权日:2000-08-24
标题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; HE YALI; YIN DONGHUA
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-4713383-A
优先权日:1984-10-01
标 题:Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
发明人：FRANCIS JOHN E; GELOTTE KARL O
权利人:CIBA GEIGY CORP
摘要:[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N-R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N-R3.

专利号:US-10479754-B2
优先权日:2015-09-16
标题 :Synthesis of methacrylic acid from methacrolein-based alkyl methacrylate
发明人：KRILL STEFFEN; GROEMPING MATTHIAS; LYGIN ALEXANDER
权利人:ROEHM GMBH
摘要:The present invention relates to a process for preparing alkyl methacrylates, especially MMA, and methacrylic acid, based on methacrolein, which has been oxidatively esterified in a second process stage. Methacrolein is obtainable in principle from C2 and C4 units. The present process has the advantage that the alkyl methacrylate and methacrylic acid can be obtained in a simple manner, in high yields and high purities, either as a mixture or as isolated product streams. In particular, the process of the invention has the great advantage that especially the ratio of the desired methacrylic acid and alkyl methacrylate, especially MMA, products can be adjusted freely within a wide range and varied by chemical engineering measures and operating parameters.

专利号:CN-104774891-B
优先权日:2015-01-15
标 题:A kind of technique of enzymatic efficient synthesis of benzyloxycarbonyl aspartame

专利号:JP-6824253-B2
优先权日:2015-09-16
标 题:Synthesis of methacrylic acid from methacrolein-based alkyl methacrylates

专利号:US-2018251418-A1
优先权日:2015-09-16
标题:Synthesis of methacrylic acid from methacrolein-based alkyl methacrylate