CAS: 928659-17-0; Sodium 7-(Methylthio)-3-Nitro-4-Oxo-4H-[1,2,4]Triazolo[5,1-C][1,2,4]Triazin-6-Ide Dihydrate

该化合物是一种复杂的有机化合物,其特点是独特的三氮和三氮环结构,有助于其潜在的生物活动.这种化合物通常具有极地溶剂的溶解性,例如由于存在钠盐和水合形式而溶解性.甲基硫和硝基替代成分增强了其再活动性,并可能影响其药用特性,使其对药用化学感兴趣.多种氮原子在其结构中的存在还可能具有特定的电子特征,可能影响其与生物目标的相互作用.作为钠盐,它有可能脱离溶解,从而影响其生物利用率和行动机制.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

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合成工艺路线路线简述

  • 603-67-8 + 45534-08-5 = 928659-17-0
    反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 0 - 5 °C1.2 Reagents: Sodium Carbonate Solvents: Isopropanol,Water; Rt; 1 H,Rt
    标题:Process For Preparation Of The Sodium Salt Of 2-Methylthio-6-Nitro-1,2,4-Triazolo[5,1-C]-1,2,4-Triazin-7-One,Dihydrate
    参考文献:Russian Federation]

    45534-08-5 + 626-35-7 = 928659-17-0
    反应条件:1.1 Reagents: Sodium Nitrite,Nitric Acid Solvents: Water; Rt -> 0 °C; 15 Min,0 °C; 10 Min,0 °C1.2 Reagents: Sodium Carbonate Solvents: Water; 2 H,0 - 5 °C
    标题:Preparation Of The Sodium Salt Of 2-Methylthio-6-Nitro-1,2,4-Triazolo[5,1-C]-1,2,4-Triazine-7-(4H)-One Dihydrate As An Antiviral Agent
    参考文献:Russian Federation]

    = 928659-17-0 [标题:Reaction Conditions
    标题:Synthetic Approaches To 1,2,4-Triazolo[5,1-C][1,2,4]Triazin-7-Ones As Basic Heterocyclic Structures Of The Antiviral Drug Riamilovir ("Triazavirin") Active Against Sars-Cov-2 (Covid-19)
    作者:Artem'Ev,Grigory A.; Rusinov,Vladimir L.; Kopchuk,Dmitry S.; Savchuk,Maria I.; Santra,Sougata; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2022 卷标:20(9) 页码:1828-1837

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主要参考文献


1: Wu X, Yu K, Wang Y, Xu W, Ma H, Hou Y, Li Y, Cai B, Zhu L, Zhang M, Hu X, Gao J, Wang Y, Qin H, Wang W, Zhao M, Wu X, Zhang Y, Li L, Li K, Du Z, Mol BWJ, Yang B. Efficacy and safety of triazavirin therapy for coronavirus disease
2019: A pilot randomized controlled trial. Engineering (Beijing). 2020 Sep 8. doi: 10.1016/j.eng.2020.08.011. Epub ahead of print.
2: Wu X, Yu K, Wang Y, Xu W, Ma H, Hou Y, Li Y, Cai B, Zhu L, Zhang M, Hu X, Gao J, Wang Y, Qin H, Zhao M, Zhang Y, Li K, Du Z, Yang B. The Efficacy and Safety of Triazavirin for COVID-19: A Trial Protocol. Engineering (Beijing). 2020 Jul 3. doi: 10.1016/j.eng.2020.06.011. Epub ahead of print.

合成参考文献


摘要:Pfeffer E, Klapsing J, Besecke C. [Influence of various carbohydrate or volatile fatty acid supplements on nitrogen metabolism in wethers]. Z Tierphysiol Tierernahr Futtermittelkd. 1975 Jul;35(2-3):101–12.
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