CAS: 80451-04-3; Cecropin A

专利信息

专利号:US-7592320-B2
优先权日:2001-07-26
标题:Cancer gene therapy based on translational control of a suicide gene
发明人：DEBENEDETTI ARRIGO; DEFATTA ROBERT J
权利人:DEBENEDETTI ARRIGO; DEFATTA ROBERT J
摘要:A novel gene therapy for cancer has been discovered, which unlike most prior approaches, does not require specific knowledge of the cancer cells, but instead targets a general characteristic that distinguishes cancer cells from normal cells, i.e., elevated eIF4E expression. The expression of a toxin or conditional toxin such as HTK is translationally repressed in normal cells by placing a complex 5′ UTR in front of its reading frame. In prototype experiments, this HTK mRNA, a transcriptional product of the BK-UTK vector, was translationally regulated so as to largely inhibit its production in normal murine and human cells, while cancer cells efficiently translated the protein, which a resulting increased sensitivity to GCV. Synthesis of the HTK protein from the BK-UTK vector (containing the 5′ UTR of Fibroblast growth factor-2 (“FGF-2â€?) readily occurred in a panel of murine and human breast carcinoma lines, but not in normal cell lines. Subcutaneous tumors and experimental lung metastases of the breast carcinoma line MM2MT in BALB/c mice were greatly reduced by transfection with the BK-UTK vector, followed by GCV administration. Both the BK-UTK and the BK-TK (control) vectors were effective in reducing lung metastasis following systemic delivery of the vectors and subsequent GCV administration. However, the BK-TK vector was highly toxic to mice while little to no toxicity was seen in mice treated with theBK-UTK vector.

专利号:US-4507230-A
优先权日:1982-05-12
标 题 :Peptide synthesis reagents and method of use
发明人：TAM JAMES P; HEATH JR WILLIAM F; MERRIFIELD ROBERT B
权利人:RESEARCH CORP
摘要:A method of releasing a functional group present in an amino acid or amino acyl residue from a resin or protecting residue which is bonded to the functional group by a linkage having proton affinity, which comprises: reacting the functional group bonded to the organic residue, with a mixture of HF and a base for a time and under conditions effective to produce the release; wherein the amounts of HF and base in the mixture are adjusted so that said release occurs substantially by an SN2 mechanism.

专利号:US-8026219-B2
优先权日:2006-04-28
标题:Antimicrobial linear peptides
发明人：RODRIGUEZ EDUARD BARDAJI; SEGUI EMILI MONTESINOS; ROMACHO ESTHER BADOSA; SOLEY LIDIA FELIU; GRABULEDA MARTA PLANAS; MALAGON RAFAEL FERRE
权利人:UNIV GIRONA
摘要:The present invention relates to novel linear peptides with antimicrobial activity. Said peptides are made up of 11 amino acids, and they have the amino group of the amino acid constituting the N-terminal end in a non-derived form or functionalized with an acetyl group, p-toluene sulphonyl, benzyl or benzoyl. The amino acid constituting the C-terminal end of said peptides is in carboxamide form. The invention describes the synthesis and use of said peptides as antimicrobial agents to combat pathogenic bacteria for plants. The invention also relates to compositions containing said peptides and an auxiliary agent, and to a method for preventing and treating infections and diseases of plants caused by pathogenic bacteria.

专利号:CN-116813791-A
优先权日:2022-07-26
标题:A kind of synthesis and determination method of cecropin and melittin hybrid antibacterial peptide

专利号:US-2021171584-A1
优先权日:2017-11-10
标题 :Cell-free protein synthesis platform derived from cellular extracts of vibrio natriegens

专利号:CN-102718844-B
优先权日:2012-06-29
标 题 :Antibacterial peptide AMitP with acid activation properties and its synthesis and application in the preparation of antitumor drugs