CAS: 7384-98-7; Propane-1,2-Diyl Dioctanoate

相似化合物

620-67-7 126-53-4 538-24-9

📜1,2-丙二醇,辛酰氯置于吡啶体系中,化学反应 12.0H,以49%的收率获得产物丙二醇二辛酸酯
参考文献:Synthesis Of Diacylglycerol Analogues As Potential Second-Messenger Antagonists And Inhibitors Of Protein Kinase C
标题:Synthesis Of Diacylglycerol Analogues As Potential Second-Messenger Antagonists And Inhibitors Of Protein Kinase C
摘要:A Series Of Analogues Of Diacylglycerol Has Been Prepared And Tested As Inhibitors Of Protein Kinase C (Pkc). The Diketone Analogues,10-Hydroxymethyl-8,13-Eicosanedione (24),10-Acetoxymethyl-8,13-Eicosanedione (25),And 10-Methoxymethyl-8,13-Eicosanedione (26) Each Inhibited Pkc Activated By 2-0-Acetyl-1-0-Oleoylglycerol. Compound 24 Was The Most Effective Inhibitor Of The Growth Of Mr4 And Ht29 Cells In Culture,And 26 Was More Effective Than 24 Against Hl60 Cells.
DOI:10.1016/0008-6215(92)85036-Y

专利信息

专利号:US-7662401-B2
优先权日:2002-04-08
标 题 :Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase
发明人：MAHE YANN; MEYBECK ALAIN
权利人:OREAL
摘要:The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.

专利号:US-12295961-B2
优先权日:2009-12-31
标 题:Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
发明人：DHINGRA OM
权利人:MARIUS PHARMACEUTICALS INC
摘要:A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of a lipophilic therapeutic agent by formulation with sterols and/or sterol esters, resulting in higher bioavailability of a therapeutic agent administered to a subject in need of such therapeutic agent. The formulation contains a therapeutic agent and a sterol or sterol ester, and can, optionally, further contain a solubilizer and/or an enhancing agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

专利号:EP-1239813-B1
优先权日:1999-12-23
标题:Extract of blue-green alga spirulina and the use thereof in cosmetic skin-care and body care agents
发明人：SCHLOTMANN KORDULA; WALDMANN-LAUE MARIANNE; JASSOY CLAUDIA; KAETEN MELANIE; KOEHLER EVA-MARIA; PULZ OTTO; KURTH ELKE
权利人:HENKEL KGAA
摘要:The invention relates to an aqueous or aqueous-alcoholic extract of the blue-green algal taxon Spirulina, characterized in that it contains at least 10 wt. % magnesium in relation to the dry weight of said extract. The inventive blue-green alga extract is an efficacious component for stimulating intracellular synthesis of ATP and matrix proteins and differentiation of keratinozytes. The blue-green alga extract is used in topical preparations for cleaning and cosmetic care of the skin and hair, in addition to the production of agents for dermatological treatment of the skin.

专利号:US-9066864-B2
优先权日:2011-01-12
标 题:Use of liquid medium exchange by cross flow filtration in the preparation of drug suspensions
发明人：NIEDERMANN HANS PETER; BOTHE HEIKO
权利人:NIEDERMANN HANS PETER; BOTHE HEIKO; INTERVET INC
摘要:Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.

专利号:WO-2012149093-A1
优先权日:2011-04-26
标 题 :2-guanidino-4-oxo-imidazoline derivatives as antimalarial agents, synthesis and methods of use thereof
发明人：LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF ARMY; LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
摘要:The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

专利号:US-9572768-B2
优先权日:2011-04-20
标 题:Cosmetic composition for use in increasing the collagen synthesis in skin cells
发明人：DOUCET OLIVIER; PUJOS MURIEL; ROBERT CÉCILE; BERNINI DOROTHÉE
权利人:DOUCET OLIVIER; PUJOS MURIEL; ROBERT CÉCILE; BERNINI DOROTHÉE; COTY GERMANY GMBH
摘要:The invention refers to a cosmetic composition for increasing collagen synthesis in skin cells comprising 0.001-0.5 wt % of a Phaeodactylum tricornutum extract, 0.00001-2.0 wt % of Dimer Tripeptide-43 or Hydrolyzed Rice Protein, and cosmetic auxiliaries. The cosmetic composition comprising the combination of both components has an synergistic effect on collagen I synthesis in skin cells and has a booster effect to other substances which are known to have an enhancing effect to collagen I synthesis.