CAS: 657-26-1; H-Lys-Oh.2Hcl

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CAS号56-87-1 L-赖氨酸 | CAS号2592-19-0 N,N'-二叔丁氧羰基-L-赖... | CAS号84624-28-2 N’-Fm°C-L-赖氨酸 | CAS号27486-90-4 L-Lysine,N6-(tr... | CAS号51866-92-3 L-Lysine,N2,N6-...

专利信息

专利号:US-8367819-B2
优先权日:2004-06-10
标 题:Synthesis of caprolactam from lysine
发明人：FROST JOHN W
权利人:UNIV MICHIGAN STATE; FROST JOHN W
摘要:In various embodiments, the present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-εcaprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.

专利号:US-3928445-A
优先权日:1973-12-26
标 题 :Synthesis of 2-halo-5-cyano alkyl valerate
发明人：ROGIC MILORAD M; MARES FRANTISEK
权利人:ALLIED CHEM
摘要:2-Halo-5-cyano alkyl valerate is produced by halogenating a 2alkoxy-3-oximinocyclohexene or the mineral acid salt thereof with at least one equivalent of chlorine, bromine or iodine; treating the 1,2-dihalo-2-alkoxy-3-oximinocyclohexane intermediate thus formed with an alcohol having 1 to 12 carbon atoms, more preferably with ethanol, methanol, propanol, butanol or isobutanol to form the corresponding 2-halo-6oximinocyclohexanone dialkyl ketal or its mineral acid salt; and ring opening of the ketal using a Beckmann cleavage reaction to form 2-halo-5-cyano alkyl valerate. The novel compound thus formed may be converted by reductive amination to form an alkyl ester of lysine which is subsequently hydrolyzed and neutralized to produce lysine.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-2523745-A
优先权日:1948-02-24
标题 :Synthesis of lysine intermediate
发明人：WARNER DONALD T; MOE OWEN A
权利人:GEN MILLS INC

专利号:WO-2025151642-A1
优先权日:2024-01-09
标题 :Modified elongation factor p and methods of use thereof
发明人：HECHT SIDNEY; DEDKOVA LARISA; POTUGANTI GAL REDDY; DASKALOVA SASHA
权利人:UNIV ARIZONA STATE
摘要:Provided herein are modified elongation factor P (EF-P) enzymes capable of incorporating noncanonical amino acids during protein synthesis at efficiencies that are different than those of native EF-P. Also provided are methods for preparing and using modified EF-P enzymes.

专利号:US-2007149777-A1
优先权日:2004-06-10
标 题 :Synthesis of caprolactam from lysine