CAS: 6345-43-3; Dimethyl Pyrimidine-4,6-Dicarboxylate

相似化合物

16490-02-1 612088-38-7 73955-53-0

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methanol pyrimidine-4,6-dicarboxylic acid 4,6-dimethylpyrimidinepyrimidine-4,6-dicarboxylic acid 4,6-dicyanopyrimidine 4-(dideutero-{[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester 4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

📜4,6-二甲基嘧啶置于potassium Permanganate,硫酸,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 27.0H,反应生成 嘧啶-4,6-二甲酸二甲酯
参考文献:Radiolabeled Selective Matrix Metalloproteinase 13 (Mmp-13) Inhibitors: (Radio)Syntheses And In Vitro And First In Vivo Evaluation
标题:Radiolabeled Selective Matrix Metalloproteinase 13 (Mmp-13) Inhibitors: (Radio)Syntheses And In Vitro And First In Vivo Evaluation
摘要:The Noninvasive Imaging Of Mmp Activity In Vivo Could Have A High Impact In Basic Research As Well As In Clinical Applications. This Approach Can Be Established Using Radiolabeled Mmp Inhibitors (Mmpis) As Tracers For The Detection Of Activated Mmps By Means Of Pet. However,The Complexity Of Diseases Associated With Dysregulated Mmp Expression Necessitates The Imaging Of Distinct Mmps Or Mmp Subgroups To Distinguish Their Individual Role In Specific Diseases. To This End,Selective And Potent Mmp-13 Inhibitors Based On A N,N'-Bis(Benzyppyrimidine-4,6-Dicarboxamide Core Have Been Synthesized And Successfully Radiolabeled With Carbon-11,Fluorine-18,And Gallium-68. Selected Radiolabeled Candidates Were Evaluated In-Vitro And In Vivo Regarding Their Pharmacokinetic Properties And Metabolic Stability.
DOI:10.1021/acs.Jmedchem.6B01284