CAS: 62568-57-4; L-Tryptophyl-L-Alanylglycylglycyl-L-Aspartyl-L-Alanyl-L-Serylglycyl-L-Glutamic Acid

上下游产品

CAS号4530-20-5 B°C-甘氨酸 | CAS号35661-39-3 Fm°C-L-丙氨酸 | CAS号71989-33-8 FM°C-O-叔丁基-L-丝氨酸 | CAS号71989-14-5 Fm°C-L-天冬氨酸-4-叔丁酯 | CAS号71989-18-9 Fm°C-O-叔丁基-L-谷氨酸 | CAS号13139-14-5 N-B°C-L-色氨酸 | CAS号56-41-7 L-丙氨酸 | CAS号56-45-1 L-丝氨酸 | CAS号56-86-0 L-谷氨酸 | CAS号56-40-6 甘氨酸

Fmoc-Trp-Ala-Gly-Gly-Asp(Obzl)-Ala-Ser(Obzl)-Gly-Glu(Obzl)-Obzl置于palladium On Activated Charcoal 氢气体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 依米地肽
参考文献:One-Pot Liquid-Phase Synthesis Of Dsip And 5-Phe-Dsip Using Fluoren-9-Yl-Methoxycarbonyl-Protected Amino Acid Pentafluorophenyl Esters
标题:One-Pot Liquid-Phase Synthesis Of Dsip And 5-Phe-Dsip Using Fluoren-9-Yl-Methoxycarbonyl-Protected Amino Acid Pentafluorophenyl Esters
摘要:Fmoc 保护的氨基酸五氟苯酯用于一锅液相合成 Delta 睡眠诱导肽 (Dsip) 和 5-Phe-Dsip.该方法的优点是操作简单,性能快,产量高,纯度高,这可能代表了一种改进的多肽合成方法.
DOI:10.1055/s-1990-27032

专利信息

专利号:WO-8203077-A1
优先权日:1981-03-10
标题:High performance peptide synthesis
发明人：VERLANDER MICHAEL S; FULLER WILLIAM DEAN; GOODMAN MURRAY
权利人:BIORESEARCH INC
摘要:Method for synthesizing a polypeptide chain on an insoluble solid support, in which an amino acid is introduced into a reactor filled with an insoluble solid support containing substituent groups reacting with this amino acid, the method consisting in coupling this amino acid to the support by a condensation reaction with the reactive substituent groups, to introduce a second analogous or different amino acid into the reactor and to couple the second amino acid to the first amino acid and to repeat the process until the desired polypeptide is obtained, the improvement being constituted by the use of a pressurized flow system making it possible to obtain rapid reactions and high production yields of the desired products.

专利号:RU-95105312-A
优先权日:1995-04-07
标题:METHOD OF SYNTHESIS OF δ-SLEEP PEPTIDE

专利号:RU-2111215-C1
优先权日:1995-04-07
标 题 :Method of synthesis of $$$-sleep peptide

专利号:RU-2111972-C1
优先权日:1995-04-07
标题:METHOD OF SYNTHESIS OF δ-SLEEP PEPTIDE

专利号:EP-1566438-A2
优先权日:1998-10-13
标 题:Stabilized bioactive peptides and methods of identification, synthesis and use
发明人：ALTMAN ELLIOT
权利人:UNIV GEORGIA RES FOUND
摘要:An intracellular selection system allows concurrent screening for peptide bioactivity andnstability. Randomized recombinant peptides are screened for bioactivity in a tightly regulatednexpression system, preferably derived from the wild-type lac operon. Bioactive peptides thusnidentified are inherently protease- and peptidase-resistant. Also provided are bioactive peptidesnstabilized by a stabilizing group at either the N-terminus, the C-terminus, or both. Thenstabilizing group can take the form of a small stable protein, such as the Rop protein,nglutathione sulfotransferase, thioredoxin, maltose, binding protein, or glutathione reductase, ornone or more proline residues.

专利号:RU-95105313-A
优先权日:1995-04-07
标题:METHOD OF SYNTHESIS OF δ-SLEEP PEPTIDE