CAS: 56353-15-2; (S)-2-(3-Acetamidopropanamido)-3-(1H-Imidazol-4-yl)Propanoic Acid

上下游产品

N-acetyl-β-alanine L-histidine

L-组氨酸置于硫酸体系中,用 氯仿 作为反应溶剂,化学反应 8.0H,反应生成 N-乙酰肌肽
参考文献:一种n-乙酰-L-肌肽的制备方法
标题:一种n-乙酰-L-肌肽的制备方法
摘要:本发明公开了一种n‑乙酰‑l‑肌肽的制备方法,属于医药中间体技术领域.该方法包括:将β‑丙氨酸进行氨乙酰化得到n‑乙酰‑β‑丙氨酸;所述n‑乙酰‑β‑丙氨酸与l‑组氨酸缩合得到n‑乙酰‑l‑肌肽.其中,N‑乙酰‑β‑丙氨酸在非极性溶剂中与酰化试剂反应得到n‑乙酰‑β‑丙氨酰氯,L‑组氨酸与有机硅烷在酸的催化下反应得到有机硅烷保护的l‑组氨酸;再将有机硅烷保护的l‑组氨酸与n‑乙酰‑β‑丙氨酰氯缩合得到有机硅烷保护的n‑乙酰‑l肌肽,加极性溶剂脱去保护基,经分离和纯化得到n‑乙酰‑l‑肌肽.或者n‑乙酰‑β‑丙氨酸与l‑组氨酸在缩合剂的作用下进行缩合得到n‑乙酰‑l‑肌肽.

专利信息

专利号:US-7595156-B2
优先权日:2003-10-23
标 题:Genes for synthesis of FR-008 polyketides
发明人：LEE SANG YUP; DENG ZIXIN; CHEN SHI; JEONG KI JUN; ZHOU XIUFEN
权利人:KOREA ADVANCED INST SCI & TECH
摘要:The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.

专利号:US-2024173256-A1
优先权日:2022-11-29
标 题:Hdl mimicking targeted drug delivery system for the treatment of solid tumors
发明人：SABNIS NIRUPAMA; LACKO ANDRAS; FUDALA RAFAL
权利人:UNIV OF NORTH TEXAS HEALTH SCIENCE CENTER
摘要:The present disclosure is directed to an SR-B1-targeting nanomicelle and compositions, methods of synthesis and methods of use thereof. The nanomicelle may be an HDL-mimetic drug delivery system and may be cross-linked with DSS. The composition may contain a therapeutic agent with the ability to treat cancers, especially sarcomas.

专利号:US-8207221-B2
优先权日:2004-01-30
标 题:Crystalline polymorphs of a CXC-chemokine receptor ligand
发明人：HU MENGWEI; YU YOUNONG; DWYER MICHAEL P; TAVERAS ARTHUR G; KIM-MEADE AGNES; YIN JIANGUO; FU XIAOYONG; MCALLISTER TIMOTHY L; ZHANG SHUYI; KLOPFER KEVIN
权利人:HU MENGWEI; YU YOUNONG; DWYER MICHAEL P; TAVERAS ARTHUR G; KIM-MEADE AGNES; YIN JIANGUO; FU XIAOYONG; MCALLISTER TIMOTHY L; ZHANG SHUYI; KLOPFER KEVIN; SCHERING CORP
摘要:The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: n n n n n n n n n n These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.

专利号:US-11465997-B2
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents
发明人：NICOLAOU KYRIACOS C; BELLAVANCE GABRIEL; BUCHMAN MAREK; PULUKURI KIRAN KUMAR; RIGOL STEPHAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

专利号:US-9815816-B2
优先权日:2005-09-30
标 题 :Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline
发明人：BLIXT JORGEN; GOLDEN MICHAEL DAVID; HOGAN PHILIP JOHN; MARTIN DAVID MICHAEL GLANVILLE; MONTGOMERY FRANCIS JOSEPH; PATEL ZAKARIYA; PITTAM JOHN DAVID; SEPENDA GEORGE JOSEPH; SQUIRE CHRISTOPHER JOHN; WRIGHT NICHOLAS CARTWRIGHT ALEXANDER
权利人:ASTRAZENECA AB; GENZYME CORP
摘要:The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

专利号:EP-2105496-B1
优先权日:2000-12-08
标题 :Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
发明人：TEMPLE GARY F; MADDEN KNUT; FAN JAMES; LEONG LOUIS; HARTLEY JAMES L; GLEESON MARTIN; CHESNUT JONATHAN D; CARRINO JOHN; BYRD DEVON R N; CHEO DAVID; BRASCH MICHAEL A
权利人:LIFE TECHNOLOGIES CORP
摘要:The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The inventions also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. The invention or prepared according the methods of the invention, and also provides kits comprising the compositions, host cells and nucleic acid molecules of the invention, which may be used to synthesize nucleic acid molecules according to the methods of the invention.