CAS: 5634-34-4; Ambuphylline

该化合物是一种化学化合物,属于一种以支气管特性著称的Xanthine衍生物,主要用于治疗哮喘和慢性阻塞性肺病等呼吸病,因为其能够放松支气管滑动肌肉,改善空气流.氨丙丙烯表现出一种中度的治疗指数,并经常与其他药物结合使用,以提高其功效.该化合物的特点是其溶液在水和有机溶剂中的溶解性,有利于其配方各种药剂.其行动机制包括抑制磷柴油酶素,导致循环氨酸酯水平上升,导致溴化.此外,氨丙烯可能会产生轻微的糖尿病效应,并可能影响心脏功能.与许多药物一样,潜在的副作用可能包括胃肠道紊乱,...

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    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    1: KAPLAN LL. DETERMINATION OF IN VIVO AND IN VITRO RELEASE OF THEOPHYLLINE AMINOISOBUTANOL IN A PROLONGED-ACTION SYSTEM. J Pharm Sci. 1965 Mar;54:457-8. doi: 10.1002/jps.2600540326.
    18:7. 31(12):1337-43.
    31:850-6.

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    摘要:Journal of Laboratory and Clinical Medicine., 31(1337), 1946
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