CAS: 5570-77-4; 4-Chloro-1-Methylpiperidine

相似化合物

154874-94-9 67848-71-9 5472-49-1

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CAS号931-20-4 N-甲基-2-哌啶酮 | CAS号103057-10-9 4-(氯甲基)-1-三苯甲基-1H-咪唑 | CAS号5382-23-0 1-甲基-4-氯哌啶盐酸盐 | CAS号106-52-5 4-羟基-1-甲基哌啶 | CAS号1445-73-4 N-甲基-4-哌啶酮 | CAS号25012-72-0 1-甲基-4-氧代哌啶-3-羧酸乙酯 | CAS号6315-60-2 N,N-二-(beta-羰基乙... | CAS号59743-88-3 10-甲氧基-4-(1-甲基-... | CAS号50706-57-5 4-二苯基亚甲基哌啶 | CAS号38089-93-9 8-氯-6,11-二氢-11-... | CAS号5382-18-3 4-氯哌啶 | CAS号34580-13-7 酮替芬 | CAS号23699-84-5 9,10-Dihydro-2-... | CAS号84163-68-8 3-(哌啶-4-基)苯并[d]异恶唑 | CAS号110-89-4 六氢吡啶 | CAS号126939-27-3 10-hydroxy-10-(... | CAS号314-03-4 匹美噻吨

1-甲基-4-哌啶醇置于氯化亚砜,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以80%的收率获得产物1-甲基-4-氯哌啶
参考文献:一种合成n-取代哌啶-4-硼酸的工艺方法
标题:一种合成n-取代哌啶-4-硼酸的工艺方法
摘要:本发明涉及有机化合物合成方法.一种合成n‑取代哌啶‑4‑硼酸的工艺方法,以n‑取代哌啶‑4‑醇为原料,先与氯化亚砜,有机碱在溶剂中反应反应生成n‑取代哌啶‑4‑氯,再以n‑取代哌啶‑4‑氯为原料,与金属锂,二(n,N‑二甲胺基)卤硼烷在溶剂中反应,淬灭酸化后得到n‑取代哌啶‑4‑硼酸.本发明工艺方法具有原创性,成本低,安全,反应条件温和,避免了其他专利方法采用昂贵的氢氧化钯加氢的危险反应,具有潜在成本优势,安全优势,适合工业化放大生产.

专利信息

专利号:US-6642385-B2
优先权日:2001-10-15
标题 :Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
发明人：WU WENXUE; LIAO HONGBIAO; TSAI DAVID J
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime dihydrochloride, monohydrochloride and free base, and similar compounds, in high stereochemical purity.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:CN-1678605-A
优先权日:2001-10-15
标题:Synthesis of 4- (piperidinyl) (2-pyridinyl) methylene- (E) -O-methyloxime and salts thereof

专利号:JP-2012530050-A
优先权日:2010-03-15
标题:Synthesis of propiverine hydrochloride

专利号:WO-2011114195-A1
优先权日:2010-03-15
标题:Synthesis of propiverine hydrochloride

专利号:EP-1436282-A1
优先权日:2001-10-15
标题 :Synthesis of 4-(piperidyl) (2-pyridyl)methanone-(e)-o-methyloxime and its salts