CAS: 53933-47-4; (S)-N-(1-Phenylethyl)Hydroxylamine

该化合物是一种有机化合物,其特征是附于苯乙基协会的氢氧基胺功能组;该化合物的形态和纯度,一般看起来无色可粉黄黄色液体或固体,因其形态和纯度而不同;以其在有机合成中的作用而著称,特别是碳基化合物氧化物的形成,并因其具有立体特性的中心,可成为非对称合成的辅助手工业; 氢氧胺组的存在具有回动性,允许其参与各种化学反应,包括核生殖器攻击和聚合反应; 此外,(S)-1-苯基乙基羟基乙基羟胺可能展示生物活动,使其对医药化学感兴趣; 在标准实验室条件下,其在极地溶剂中的溶解性和稳定性进一步提高了其在合成应用中的效用;与许多有机化合物一样,适当的处理和安全防范措施至关重要,因为其反应和毒性具有潜在的危害.

结构式图片

物理性质

MSDS等安全信息

上下游产品

acetophenone oxime N-α-methyl benzyl-O-benzoyl hydroxylamine hydr°Chloride tin(II) benzenethiolate (1-nitroethyl)benzene N-(1-phenylethyl)-N-hydroxyurea N-α-methyl benzyl-O-benzoyl hydroxylamine N-Hydroxy-N-(1-phenyl-ethyl)-benzamide N-benzylidene-1-phenylethanamine N-oxide

合成工艺路线路线简述

    📜(S)-(-)-α-甲基苄胺置于过氧化脲素体系中,用 乙醚 作为反应溶剂,化学反应 1.0H,以95%的收率获得产物(S)-1-苯基乙基羟基胺
    参考文献:超声促进的银纳米颗粒修饰的硫脲官能化磁性羟基磷灰石的合成:一种强大的无机-有机杂化纳米催化剂,用于氧化和还原反应
    标题:超声促进的银纳米颗粒修饰的硫脲官能化磁性羟基磷灰石的合成:一种强大的无机-有机杂化纳米催化剂,用于氧化和还原反应
    摘要:在这项研究中,基于将银纳米颗粒(agnps)固定在硫脲官能化的磁性羟基磷灰石上,超声合成被用于制造新型催化剂.通过在硫脲改性的磁性羟基磷灰石表面上修饰agnps,可构建可回收的ag纳米催化剂.磁性羟基磷灰石用作催化剂的有机-无机杂化载体.有机-无机杂化载体是通过共沉淀制备的,然后通过共价官能化1-(3,5-双(三氟甲基)苯基)-3-丙基)硫脲进行表面改性.通过透射电子显微镜(tem),扫描电子显微镜(sem),粉末x射线衍射(xrd),核磁共振(NMR),傅里叶变换红外光谱(ftir)对制备的催化剂进行了表征 热重分析(tga)和brunauer-emmett-teller(bet)分析.纳米粒子的形状大多为管状,其粒径小于100 Nm.这种纳米催化剂在不同的反应中显示出有效而强大的催化活性,包括通过应用nabh选择性还原4-硝基苯酚(4Np)和氧化伯胺4和过氧化氢脲(uhp)分别作为试剂
    DOI:10.1039/d0Nj00829J

    海关参考信息

    专利信息


    专利号:US-4376207-A
    优先权日:1980-08-18
    标 题 :Chiral synthesis of amino sugars
    发明人：USKOKOVIC MILAN R; WOVKULICH PETER M
    权利人:HOFFMANN LA ROCHE
    摘要:A simple and economic chiral synthesis of optically active methyl L-acosaminide and methyl L-daunosaminide from propenyl acetate, said methyl L-acosaminide and methyl L-daunosaminide being coupling agents for the production of known antitumor agents.

    专利号:US-4324726-A
    优先权日:1979-07-25
    标题 :Chiral synthesis of amino sugars
    发明人：USKOKOVIC MILAN R; WOVKULICH PETER M
    权利人:HOFFMANN LA ROCHE
    摘要:A simple and economic chiral synthesis of optically active methyl L-acosaminide and methyl L-daunosaminide from propenyl acetate, said methyl L-acosaminide and methyl L-daunosaminide being coupling agents for the production of known antitumor agents.

    专利号:US-4414402-A
    优先权日:1981-12-02
    标 题:[2S-(2β,2S*, 3β)]-3-Aminotetrahydro-5-methoxy-α-methyl-2-furanmethanol, an intermediate in the chiral synthesis of amino sugars
    发明人：USKOKOVIC MILAN R; WOVKULICH PETER M
    权利人:HOFFMANN LA ROCHE
    摘要:A simple and economic chiral synthesis of optically active methyl L-acosaminide and methyl L-daunosaminide from propenyl acetate, said methyl L-acosaminide and methyl L-daunosaminide being coupling agents for the production of known antitumor agents.

    专利号:US-8084630-B2
    优先权日:2007-05-31
    标 题 :Process for the synthesis of ramelteon and its intermediates
    发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
    权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
    摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

    专利号:US-2009281176-A1
    优先权日:2007-11-01
    标题:Process for the synthesis of ramelteon and its intermediates
    发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
    权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
    摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

    专利号:WO-2009056993-A2
    优先权日:2007-11-01
    标题 :A process for the synthesis of ramelteon and its intermediates

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    主要参考文献

    参考标题:A General Procedure For The Synthesis Of Isoxazolidin-5-Ones
    作者:Jack E. Baldwin,Laurence M. Harwood,Michael J. Lombard
    摘要:Conjugate Addition Of N-Substituted Hydroxylamines To α,β-Unsaturated Esters Followed By Cyclisation Of The Adducts With Lithium Bis (Trimethylsily)Amide Provides The First General Means Of Synthesising Isoxazolidin-5-Ones, The N-Benzyl Derivatives Of Which May Be Hydrogenolised To β-Aminoacids.

    合成参考文献


    摘要:Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 966.
    摘要:Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 948.
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