CAS: 471-62-5; Hopane

上下游产品

(4S,5R)-4-Benzyloxymethyl-2,2-dimethyl-5-(R)-oxiranyl-[1,3]dioxolane 1,4-bis-O-benzyl-2,3-O-isopropylidene-5-aldehydo-D-ribitol benzyl 2,3-O-isopropylidene-β-D-ribo-pentodialdo-1,4-furanoside (21)-eneHop-17(21)-ene

📜Dryocrassol置于三丁基膦,4,4'-Di(Tert-Butyl)-[1,1-Biphenyl]Yllithium体系中,用 四氢呋喃,吡啶 作为反应溶剂,化学反应生成 甲苯二异氰酸酯
参考文献:复杂的生物类人猿合成:核糖基亚基的有效锚定到c(30)hop烷上.
标题:复杂的生物类人猿合成:核糖基亚基的有效锚定到c(30)hop烷上.
摘要:细菌类胡萝卜素代表了一个特别重要的三萜类化合物系列,广泛分布于细菌中.这些五环hop烷多元醇的共同特征之一是存在延伸的非萜类和多羟基化侧链,这些侧链通过cc键与三萜部分相连.当人们考虑侧链中结构和功能的广泛多样性时,也必须解决生物类胡萝卜素的生物学功能.此外,由于缺乏合成类胡萝卜素的合成方法,某些类生物类胡萝卜素的立体化学仍未得到证实.在这项研究中,我们描述了一种通过使用a基锂中间物在c(30)-戊烷组分和c(5)-多羟基化碳水化合物之间形成c-C键的有效方法,这使我们能够合成几种生物类类胡萝卜素衍生物.我们还报告了在位置c31处带有一个额外羟基的hop烷戊醇的首次合成.
DOI:10.1002/chem.200600659

专利信息

专利号:WO-0183769-A9
优先权日:2000-05-03
标 题 :Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
发明人：NOEL JOSEPH P; BOWMAN MARIANNE E; RICHARD STEPHANE
权利人:SALK INST FOR BIOLOGICAL STUDI; NOEL JOSEPH P; BOWMAN MARIANNE E; RICHARD STEPHANE
摘要:The present invention provides the structure of the enzyme 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) synthase, a member of the cytidyltransferase family of enzymes. CDP-ME is a critical intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis in a number of prokaryotic organisms, in algae, in the plastids of plants, and in the malaria parasite. Since vertebrates synthesize isoprenoid precursors using a mevalonate pathway, CDP-ME synthase and other enzymes of the mevalonate-independent pathway for isoprenoid production represent attractive targets for the structure-based design of selective antibacterial, herbicidal, and antimalarial drugs. Accordingly, the present invention provides methods for screening for compounds that inhibit enzymes of the mevalonate-independent pathway and pharmaceutical compositions and antibacterial formulations thereof. Further provided are methods of inhibiting the enzymes of the pathway and bacterial terpenoid synthesis and methods for treating a subject suffering from a bacterial infection.

专利号:US-7286973-B1
优先权日:2000-05-03
标题:Method of screening inhibitors of mevalonate-independent isoprenoid biosynthetic pathway
发明人：NOEL JOSEPH P; BOWMAN MARIANNE E; RICHARD STEPHANE
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:The present invention provides the structure of the enzyme 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) synthase, a member of the cytidyltransferase family of enzymes from Escherichia coli . CDP-ME is a critical intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis in a number of prokaryotic organisms, in algae, in the plastids of plants, and in the malaria parasite. Since vertebrates synthesize isoprenoid precursors using a mevalonate pathway, CDP-ME synthase and other enzymes of the mevalonate-independent pathway for isoprenoid production represent attractive targets for the structure-based design of selective antibacterial, herbicidal, and antimalarial drugs. Accordingly, the present invention provides methods for screening for compounds that inhibit enzymes of the mevalonate-independent pathway and pharmaceutical compositions and antibacterial formulations thereof. Further provided are methods of inhibiting the enzymes of the pathway and bacterial terpenoid synthesis and methods for treating a subject suffering from a bacterial infection.

专利号:WO-0183769-A2
优先权日:2000-05-03
标题 :Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis

专利号:CN-119410676-A
优先权日:2025-01-07
标题:Hopane synthesis gene combination and application thereof in enhancing environmental stress tolerance of rhizobia in wide hosts