CAS: 34583-34-1; (3S)-1-Azabicyclo[2.2.2]Octan-3-Ol

上下游产品

CAS号3731-38-2 3-奎宁环酮

N-乙酸乙酯-4-哌啶甲酸乙酯置于potassium Tert-Butylate,水,Sodium Hydroxide体系中,用 乙醇,水,甲苯 用作溶剂,化学反应 9.83H,反应生成(S)-(+)-3-喹宁醇
参考文献:一种光学活性3-奎宁醇的制备方法
标题:一种光学活性3-奎宁醇的制备方法
摘要:本发明涉及一种中间体的合成方法,属于有机合成领域.具体说是一种操作简便,成本低廉,适用于工业化生产的光学活性3‑奎宁醇的制备方法.以4‑哌啶甲酸为起始原料,通过酯化,亲核取代,Dieckmann缩合,脱羧,成盐,还原,乙酰化,化学拆分等得到中间体光学活性3‑奎宁醇.上述的反应式如下:

专利信息

专利号:US-5569447-A
优先权日:1994-04-19
标 题:Stannylated 3-quinuclidinyl benzilates and methods of preparing radiohalogenated derivatives
发明人：LEE KAN S; HE XIAO-SHU; WEINBERGER DANIEL R
权利人:US HEALTH
摘要:The present invention provides stannylated 3-quinuclidinyl benzilate compounds and a method of synthesizing *AQNB by iodinating such stannylated 3-quinuclidinyl benzilate compounds. The iodination of these stannylated 3-quinuclidinyl benzilates proceeds in as little as five minutes; thus, the stannylated 3-quinuclidinyl benzilates may be converted to *AQNB in situ for immediate use. Using this method, radiolabelling yields as high as 80% have been observed. The present invention also is directed towards a method of synthesis of the stannylated 3-quinuclidinyl benzilate compounds. The method comprises providing a 4'-halo-3-quinuclidinyl benzilate and reacting the 4'-halo-3-quinuclidinyl benzilate with a compound having the formula (SnR 3 ) 2 , wherein R is an alkyl.

专利号:US-6054464-A
优先权日:1996-02-23
标题:Azabicyclic esters of carbamic acids useful in therapy
发明人：MACOR JOHN; WU EDWIN
权利人:ASTRA AB
摘要:A compound of formula ##STR1## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C--R 4 ; R 1 is hydrogen or methyl; R 2 is hydrogen or fluoro; R 3 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 4 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; n or R 2 and R 3 or R 3 and R 4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 5 and R 6 are independently hydrogen or C 1 to C 3 alkyl; n or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing the, compositions containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders, as well as intermediates and use of intermediates in synthesis.

专利号:CN-112941041-B
优先权日:2021-02-18
标 题:A kind of quinine reductase and its application in the asymmetric synthesis of (R)-3-quinine alcohol

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:EP-0685442-B1
优先权日:1994-05-27
标题:Reagent and process for the Synthesis of esters and transesterifiable xanthates

专利号:EP-0685442-A1
优先权日:1994-05-27
标题:Reagent and process for the Synthesis of esters and transesterifiable xanthates