CAS: 2965-16-4; 2'-Chloro-5'-Fluoroacetophenone

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CAS号352-33-0 对氯氟苯 | CAS号75-36-5 乙酰氯 | CAS号62433-39-0 4-(2-chloro-5-f... | CAS号62433-47-0 4-(2-chloro-5-f...

2-氯-5-氟苯甲酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成2-氯-5-氟苯乙酮
参考文献:Pi3K Inhibitors And Methods Of Making And Using The Same
标题:Pi3K Inhibitors And Methods Of Making And Using The Same
摘要:The Disclosure Is In Part Directed To Solid Forms Of (S)-N-(8-(2-Chloro-5-Fluorophenyl)-3-(Methylcarbamoyl)-6-Oxo-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazin-1-yl)Benzo[d]Isothiazole-3-Carboxamide,Its Salts,Its Crystalline Forms,And Variants Thereof.

专利信息

专利号:US-8513241-B2
优先权日:2008-03-28
标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
发明人：CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.