CAS: 2404-87-7; 3-Phenylthiophene

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CAS号872-31-1 3-溴噻吩 | CAS号98-80-6 苯硼酸 | CAS号6165-69-1 3-噻吩硼酸 | CAS号108-86-1 溴苯 | CAS号108-90-7 氯苯 | CAS号17249-80-8 3-氯噻吩 | CAS号960-16-7 三丁基苯基锡 | CAS号2633-57-0 三烯丙基(苯基)硅烷 | CAS号591-50-4 碘苯 | CAS号143203-11-6 5-chloro-2-iodo... | CAS号23062-41-1 Thiophene,3-bro... | CAS号19698-46-5 2,5-二溴-3-苯基噻吩 | CAS号97272-02-1 5-苯基-2-噻吩磺酰氯 | CAS号10341-88-5 3-苯基噻吩-2-羧酸 | CAS号362612-68-8 4-苯基噻吩-2-硼酸 | CAS号3328-86-7 2,4-diphenylthi... | CAS号26170-87-6 4-苯基噻吩-2-甲醛

📜苯基三氯硅烷置于四丁基氟化铵体系中,用 四氢呋喃,乙醚,水 用作溶剂,化学反应 28.0H,反应生成3-苯基噻吩
参考文献:三烯丙基(芳基)硅烷与芳基溴化物和氯化物的交叉偶联:一种替代的便捷联芳基合成
标题:三烯丙基(芳基)硅烷与芳基溴化物和氯化物的交叉偶联:一种替代的便捷联芳基合成
摘要:在dmso-H 2 O中存在pdcl 2 / Pcy 3和氟化四丁基铵(tbaf)的情况下,多种芳基溴化物与三烯丙基(芳基)硅烷的交叉偶联是有效的,以高收率得到各种联芳基.值得一提的是,全碳取代的芳基硅烷对水分,酸和碱稳定,易于获得,可作为其芳基(卤代)硅烷对应物的高度实用替代品.由[(η的催化剂体系3-C 3 H ^ 5)的pdcl] 2和2-[2,4,6-(我-Pr)3 C ^ 6 ħ 2 ]-C 6 H ^ 4 Pcy2和在thf-H 2 O中使用tbaf.3 H 2 O对于与芳基氯的交叉偶联特别有效.两种催化剂体系均能耐受多种常见的官能团.推测反应的高效率归因于用tbaf.3 H 2 O和适量的水处理后烯丙基的易裂解.二烯丙基(二苯基)硅烷还可以与各种芳基溴化物和氯化物交联,收率很高,而烯丙基(三苯基)硅烷只能以中等收率得到交联产物.通过溴氯苯与不同芳基硅烷的顺序交叉偶联,可
Doi:10.1002/adsc.200404188

专利信息

专利号:US-4171439-A
优先权日:1975-04-11
标 题 :Antibacterial analogs of isocephalosporins
发明人：CONWAY TERRY T; LIM GARY M F; MENARD MARCEL
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo or hydroxyl and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-3822289-A
优先权日:1972-04-17
标题:Synthesis of thiophens
发明人：CLARK N; WEBSTER W
权利人:SYNTHETIC CHEMICALS LTD
摘要:THIOPENS ARE MADE BY REACTING ORGANIC COMPOUNDS HAVING A CONSECUTIVE CHAIN OF AT LEAST FOUR CARBON ATOMS WITH CARBON DISULPHIDE OR CARBONYL SULPHIDE IN A VAPOR PHASE REACTION IN THE PRESENCE OF A CATALYST.

专利号:US-7320993-B1
优先权日:1997-12-17
标题 :Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
发明人：BIEDERMANN ELFI; HASMANN MAX; LOESER ROLAND; RATTEL BENNO; REITER FRIEDEMANN; SCHEIN BARBARA; SEIBEL KLAUS; VOGT KLAUS; WOSIKOWSKI KATJA; SCHEMAINDA ISABEL
权利人:ASTELLAS DEUTSCHLAND GMBH
摘要:The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.

专利号:US-4112230-A
优先权日:1975-04-11
标题 :Δ2,3 -1,4 Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：MENARD MARCEL; LIM GARY M F; CONWAY TERRY T
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acylamino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-4118566-A
优先权日:1975-07-23
标 题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：HORNING DONALD E; MORRIS LEESON R; DOUGLAS JAMES L
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is amino, azido or acylamido and Z represents optionally substituted C1-C6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-4166906-A
优先权日:1975-04-11
标题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：CONWAY TERRY T; LIM GARY M F; MENARD MARCEL
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is hydroxyl esterified with a sulfonic acid residue and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group of the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.