CAS: 2338-76-3; 3-(Trifluoromethyl)Phenylacetonitrile

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CAS号151-50-8 氰化钾 | CAS号402-23-3 3-(三氟甲基)苯甲酰溴 | CAS号705-29-3 3-三氟甲基氯苄 | CAS号22902-93-8 [3-(三氟甲基)苯基]乙酰胺 | CAS号401-78-5 间溴三氟甲苯 | CAS号143-33-9 氰化钠 | CAS号401-79-6 3-甲基三氟甲苯 | CAS号349-75-7 3-(三氟甲基)苄醇 | CAS号402-26-6 间(三氟甲基)苯基溴化镁 | CAS号455-01-6 3-(三氟甲基)苯乙醇 | CAS号351-35-9 3-(三氟甲基)苯乙酸 | CAS号146621-92-3 N-B°C-3-三氟甲基-DL-苯甘氨酸 | CAS号21172-31-6 2-(3-(三氟甲基)苯基)乙醛 | CAS号1997-80-4 1-(2-溴乙基)-3-(三氟甲基)苯 | CAS号29786-43-4 1-(3-(三氟甲基)苯基)环... | CAS号242475-26-9 3-三氟甲基-DL-苯甘氨酸 | CAS号62451-84-7 3-三氟甲基苯乙酸甲酯 | CAS号52516-30-0 3-(三氟甲基)苯乙胺 | CAS号62738-99-2 3-二甲基氨基-2-[3-(三...

三氟甲苯置于氯磺酸,硫酸,四丁基溴化铵体系中,用 水 用作溶剂,化学反应 24.0H,反应生成间三氟甲基苯乙腈
参考文献:一种1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法
标题:一种1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法
摘要:本发明属于化学中间体技术领域,具体涉及一种1‑苯基‑3‑(3‑三氟甲基苯基)‑2‑丙酮的合成方法.本发明以化合物a作为基础原料,依次通过blanc氯甲基化,取代反应,克莱森酯缩合,水解反应,从而得到1‑苯基‑3‑(3‑三氟甲基苯基)‑2‑丙酮,本发明为1‑苯基‑3‑(3‑三氟甲基苯基)‑2‑丙酮的合成,提供了一种纯度高,收率高且操作简单的1‑苯基‑3‑(3‑三氟甲基苯基)‑2‑丙酮的合成方法.

专利信息

专利号:US-5811586-A
优先权日:1996-05-29
标 题 :Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one intermediate in the synthesis of the fenfluramine
发明人：CANNATA VINCENZO; GALBIATI BARBARA; SPREAFICO ANGELO
权利人:ALFA CHEM ITAL
摘要:A process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine consists of reacting the diazonium salt of 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in the presence of a catalytic amount of a cuprous salt and, optionally, of a base and purifying the crude product through the bisulfite complex or distillation under vacuum.

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:WO-2021078995-A1
优先权日:2019-10-25
标 题 :Selective polypeptide synthesis stalling assay and compound
发明人：STROUS GERARDUS JACOBUS ANTONIUS MARIA; MOL JAN ADRIANUS; VAN DER VELDEN LIEKE MARIE; KLUMPERMAN JUDITH; MAAS PETRUS EMMANUEL MARIE; PIET DENNIS PATRICK; DE KLERK-SPRENKELS NANDA ELISABETH; TIJHUIS JOHANN HEINRICH; VIÉTOR HENDRIK ENGELBERTUS; MAURICE MADELON MARIA; VAN DER KRIFT FELIX
权利人:UMC UTRECHT HOLDING BV; UNIV UTRECHT HOLDING BV; BIMINI BIOTECH B V
摘要:The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.

专利号:US-5089639-A
优先权日:1988-09-01
标题:N-cycloalkylalkylamines, process for their preparation, their use as a medicament and their synthesis intermediates
发明人：AUBARD GILBERT G; CALVET ALAIN P; DEFAUX JEAN-PIERRE; GOURET CLAUDE J; GROUHEL AGNES M; JACOBELLI HENRY L; JUNIEN JEAN-LOUIS; PASCAUD XAVIER B; ROMAN FRANCOIS F; HUDSPETH JAMES P; LIN YUAN
权利人:JOUVEINAL SA
摘要:N-Cycloalkylalkylamines of formula I: ##STR1## in which: R1 is phenyl which is optionally mono-, di- or trisubstituted by halogens or lower alkyl, haloalkyl or lower alkoxy radicals, or is an aromatic heterocyclic radical having 5 to 7 chain members, in which the hetero atom is nitrogen, oxygen or sulphur, n R2 is lower alkyl, n R3 is hydrogen or lower alkyl, n m has the value of 1 or 2, n R4 is cycloalkyl --CH(CH2)n, in which a carbon atom may carry a radical Rx, which is lower alkyl or phenyl; and in which n has the values from 2 to 5, n R5 is phenyl, which can be mono-, di- or trisubstituted by halogens or by lower alkoxy radicals, and n Q represents an ethylene-1,2-diyl group --CHâ•?CH-- or a cyclopropane-1,2-diyl group ##STR2##

专利号:EP-0810195-A1
优先权日:1996-05-29
标题:Process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the fenfluramine

专利号:US-5393730-A
优先权日:1993-01-12
标题 :Nicotinic acid hydrazone compounds which have useful herbicidal compositions
发明人：SMITH PHILIP HENRY GAUNT
权利人:RHONE POULENC AGRICULTURE
摘要:The invention relates to nicotinic acid hydrazone derivatives of formula I: ##STR1## in which the various symbols are as defined in the description, and their use as herbicides or as intermediates in the synthesis of herbicides.