CAS: 23323-37-7; (2R,3R,4R,5S)-6-(Octylamino)Hexane-1,2,3,4,5-Pentaol

N-octyl-D-Glucamine Salt 5-Methyl-(6S)-Tetrahydrofolic Acid置于盐酸体系中,用 水 用作溶剂,化学反应生成L-5-甲基四氢叶酸,N-正辛基-D-葡萄糖胺
参考文献: Resolution Of Tetrahydrofolic Acid Derivatives[fr] Séparation De Dérivés D'Acide Tétrahydrofolique
标题: Resolution Of Tetrahydrofolic Acid Derivatives[fr] Séparation De Dérivés D'Acide Tétrahydrofolique
摘要:制备(6S)-四氢叶酸衍生物的过程包括将外消旋(6Rs)-四氢叶酸衍生物与n-烷基-D-葡糖胺反应,形成(6Rs)-四氢叶酸衍生物的n-烷基-D-葡糖胺盐,分离出(6S)-四氢叶酸衍生物的n-烷基-D-葡糖胺盐,去除n-烷基-D-葡糖胺阳离子,并纯化(6S)-四氢叶酸衍生物.然后,纯化的(6S)-四氢叶酸衍生物可以转化为相应的碱金属或碱土金属盐.

专利信息

专利号:US-8168828-B2
优先权日:2007-06-25
标题 :Process for the preparation of pregabalin
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; SATYANARAYANA REVU
权利人:SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; SATYANARAYANA REVU; MSN LAB LTD
摘要:The present invention encompasses novel intermediates of pregabalin, namely 3-cyano-5-methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregabalin intermediates into pregabalin, Formula (I): The present invention further provides a cost effective method for the synthesis of (S)-pregabalin, which involves the recovery of mandelic acid and tartaric acid used in the resolution process and recycling them, increasing the yields of the final product formed, which substantially reduced the cost of the production.

专利号:WO-2025019943-A1
优先权日:2023-07-24
标题:Small molecule ice recrystallization inhibitors and methods of use thereof
发明人：BEN ROBERT N; DIAMANTE MARCUS
权利人:UNIV OTTAWA
摘要:The present application provides ice recrystallization inhibitors, and methods of synthesis and use thereof. The ice recrystallization inhibitor (IRI) compounds have the structure of Formula (A) where B is an alkyl, or substituted or unsubstituted phenyl. The IRI compounds exhibit good IRI activity and are soluble in water and in buffers, such as those used in cryopreservation.

专利号:US-9051291-B2
优先权日:2012-03-28
标题 :Process for producing (S)-equol
发明人：DAHANUKAR VILAS HARESHWAR; KUNHIMON SYAM KUMAR UNNIARAN; TIMMANA UPADHYA; PAL ABIR KUMAR; MACHA MAHENDAR; MEESALA VENKATA MADHUBABU; THALABATHULA KRISHNA MOHAN; RAMANATHAN SHANKAR
权利人:REDDYS LAB LTD DR
摘要:The present application relates to an improved process for the preparation of (S)-equol (1). The present application also relates to novel intermediates of formula (7), (7A), (8) and (9) and their use for the synthesis of (S)-equol.