CAS: 22720-75-8; 2-Acetylbenzothiophene

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N,N-二乙基乙酰胺 以 甲苯 用作溶剂,化学反应生成2-乙酰基苯并噻吩
参考文献:Process For Production Of 2-Acetylbenzo[b]Thiophene
标题:Process For Production Of 2-Acetylbenzo[b]Thiophene
摘要:生产2-乙酰基苯并[b]噻吩的方法,其化学式为(I):##str1## 包括以下步骤:(1)将化学式(II)表示的2-卤代苯甲醛:##str2## 其中x代表卤素原子,与化学式(III)表示的化合物反应:H.Sub.I S.Sub.J M.Sub.K 其中m代表碱金属,I代表零或1,J代表至少1的整数,K代表1或2的整数,并最好还与硫反应;以及(2)将反应产物与化学式(Iv)表示的单卤代丙酮反应:##str3## 其中x^1代表卤素原子.

专利信息

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:WO-9921828-A1
优先权日:1997-09-25
标题:Synthesis and isolation of n-(aryl or heteroaryl)-alkyl-n-hydroxyurea
发明人：HENGEVELD JOHN E; LEESE ELISE; MOON BRIAN S; ABAD DENNIS M; ALLEN KIMBERLY A; BAUER PHILIP E; MURPHEY DAVID B; FOHEY BRIAN T; COPP RICHARD R JR; LANNOYE GREGORY S; MITTAG RODNEY M; DIGHE NAREN
权利人:ABBOTT LAB
摘要:The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[b]thienyl substituted N-hydroxyurea of formula (I) from compound (1) by reacting compound (1) with hydroxyurea and acid. R1 is selected from the group consisting of hydrogen, 1-6 carbon alkyl, 1-6 carbon alkoxy, and halogen; R2 is an 1-4 carbon alkyl; and R3 is selected from the group consisting of hydrogen, acyl, methyl, ethyl and mixtures thereof. Additional steps to isolate the pure bulk product follow.

专利号:US-6080874-A
优先权日:1997-09-25
标题:Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydroxyurea
发明人：HENGEVELD JOHN E; LEESE ELISE H; MOON BRIAN S; ABAD DENNIS M; ALLEN KIMBERLY A; BAUER PHILIP E; MURPHEY DAVID B; FOHEY BRIAN T; COPP JR RICHARD R; LANNOYE GREG S; MITTAG RODNEY M
权利人:ABBOTT LAB
摘要:The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[b]thienyl substituted N-hydroxyurea of formula: from compound 1: by reacting compound 1 with hydroxyurea and acid. R1 is selected from the group consisting of hydrogen, 1-6 carbon alkyl, 1-6 carbon alkoxy, and halogen; R2 is an 1-4 carbon alkyl; and R3 is selected from the group consisting of hydrogen, acyl, methyl, ethyl and mixtures thereof. Additional steps to isolate the pure bulk product follow.

专利号:US-2015057451-A1
优先权日:2012-03-01
标 题 :Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols

专利号:CN-119143577-A
优先权日:2023-06-14
标 题 :Synthesis of homopropargyl tertiary alcohols containing two adjacent chiral centers

专利号:WO-2013131043-A1
优先权日:2012-03-01
标 题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols