CAS: 2127-05-1; 2-(Pyridin-4-yl)Ethane-1-Thiol

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5344-27-4 120277-01-2 13258-63-4

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CAS号100-43-6 4-乙烯基吡啶 | CAS号78092-91-8 2-[(2-吡啶-4-基乙基)硫代]乙醇

📜4-吡啶乙硫醇盐酸盐置于sodium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 0.5H,以82%的收率获得4-巯乙基吡啶
参考文献:基于ph值的ru基前药活化机理的研究
标题:基于ph值的ru基前药活化机理的研究
摘要:基于ru Iii的前药aziru有效结合蛋白质,但其释放机理仍存在争议.在此,为了检验从蛋白质中还原介导的ru释放的假说,在两个不同的氧化状态ru Ii和ru Iii中,拉曼辅助晶体学研究了aziru与模型蛋白(蛋清溶菌酶)的结合,进行了.我们的结果表明ru还原,但是还原后ru的释放取决于还原剂.为了更好地理解该过程,还对aziru-官能化的au电极进行了ph依赖的光谱电化学表面增强拉曼散射(sers)研究,作为ru Ii-和ru Iii的替代和最简单的模型系统.药物.这项sers研究为ru Iii态的水合aziru提供了6.0+/-0.4的ap K A,该水落在ph值的分水岭范围内,使大多数癌症环境与生理环境分离开来.这些实验还表明,在酸化后,氧化还原电位e 0的变化幅度大于600 Mv的含水aziru朝着更正的电位方向移动,表明癌症管腔中选择性的aziru降低,但在健康管腔中则没有.预期配
Doi:10.1021/acs.Inorgchem.8B02667

专利信息

专利号:US-5300703-A
优先权日:1993-04-05
标 题:Alkylphenol synthesis using heteropoly acid catalysts
发明人：KNIFTON JOHN F
权利人:TEXACO CHEMICAL
摘要:Disclosed is a one step method for synthesis of alkylphenols which comprises reacting phenol with the corresponding olefin under adiabatic conditions in the presence of a catalyst comprising a heteropoly acid represented by the structure: H8-n(XM12O40) where x=P or Si, M=Mo or wv and n is an integer which is 4 or 5, alone, or deposited on an inert support, at a temperature of from 60 degrees C. to 250 degrees C. and a pressure of from near atmospheric to about 500 psi.

专利号:US-5171896-A
优先权日:1992-03-05
标 题 :Alkylphenol synthesis using acid-modified inorganic clay catalysts
发明人：KNIFTON JOHN F; SHEU YU-HWA E
权利人:TEXACO CHEMICAL
摘要:Disclosed is a one step method for synthesis of alkylphenols which comprises reacting phenol with the corresponding olefin under adiabatic conditions in the presence of a catalyst comprising an acidic montmorillonite clay having the structure: Mx/nn+xyH2O(Al4-xMgx)(Si8)O20(OH)4 where M represent the interlamellar (balancing cation, normally sodium or lithium) and x, y and n are integers, wherein the acidic clay has been pretreated with an acid and optionally has deposited thereon an acid selected from the group consisting hydrogen fluoride, a fluorosulfonic acid or a mineral acid, at a temperature of from 60 DEG C. to 250 DEG C. and a pressure of from near atmospheric to about 500 psi.

专利号:US-5276215-A
优先权日:1993-04-09
标题 :Alkylphenol synthesis using zeolites as catalysts, particularly dealuminized y-zeolites
发明人：KNIFTON JOHN F; SHEU YU-HWA E; DAI PEI-SHING
权利人:TEXACO CHEMICAL
摘要:Disclosed is a one-step method for synthesis of alkylphenols which comprises reacting phenol with the corresponding olefin under adiabatic conditions in the presence of a zeolite catalyst, preferably a dealuminated Y-zeolite, a modified Y-zeolite, or a β-zeolite.

专利号:US-2024262834-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof
发明人：CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

专利号:US-4500535-A
优先权日:1979-10-15
标 题:Method of regulating the immune response with pyridine derivatives
发明人：LOMBARDINO JOSEPH G; HARBERT CHARLES A
权利人:PFIZER
摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)-pyridine [alternatively named 2-(4-picolylthio)acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.

专利号:US-7112702-B2
优先权日:2002-12-12
标题:Process for the synthesis of bisphenol
发明人：CARVILL BRIAN; GLASGOW KATHERINE; KISHAN GURRAM; KRISHNAMURTI RAMESH; KUKALYEKAR NILESH KUMAR PARKAS; RAMANARAYANAN G V
权利人:GEN ELECTRIC
摘要:A commercial scale continuous process for the production of a bisphenol comprising reacting a phenol and a ketone in the presence of a modified ion exchange resin catalyst, wherein said modified ion exchange resin comprises a crosslinked gellular acid functionalized polystyrene resin modified by neutralization of with a mercapto promoter.