CAS: 182431-12-5; N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Ylcarboxamido)Piperidin-1-yl)Butyl)-9H-Fluorene-9-Carboxamide

上下游产品

9-{4-[4-({[4'-(Trifluoromethyl)Biphenyl-2-Yl]Carbonyl}Amino)Piperidin-1-Yl]Butyl}-9H-Fluorene-9-Carboxylic Acid
9-(4-Hydroxybutyl)-N-(2,2,2-Trifluoroethyl)-9H-Fluorene-9-Carboxamide
9-(4-溴丁基)-N-(2,2,2-三氟乙基)-9H-芴-9-甲酰胺 9-(4-Bromobutyl)-N-(2,2,2-Trifluoroethyl)-9H-Fluorene-9-Carboxamide 182438-98-8
9-(4-Bromo-Butyl)-9H-Fluorene-9-Carboxylic Acid Chloride 331767-53-4
Methyl 9-(4-Bromobutyl)-9H-Fluorene-9-Carboxylate
9-(4-Hydroxybutyl)-9H-Fluorene-9-Carboxilic Acid
9-(4-溴丁基)-9H-芴-9-羧酸 9-(4-Bromo-Butyl)-9H-Fluorene-9-Carboxylic Acid 182438-97-7
4-Trifluoromethylbiphenyl-2-Carboxylic Acid (1-Benzylpiperidin-4-yl)Amide 182439-40-3

📜4-三氟甲基-联苯-2-甲酸置于20% Palladium Hydroxide-Activated Charcoal,Potassium Carbonate体系中,用 甲醇,乙醇,N,N-二甲基甲酰胺,乙腈,环己烯 用作溶剂,化学反应 26.5H,反应生成N-(2,2,2-三氟乙基)-9-(4-[4-[4'-(三氟甲基)[1,1'-联苯]-2-甲酰氨基]哌啶-1-基]丁基)-9H-芴-9-甲酰胺
参考文献: Process For The Preparation Of Lomitapide[fr] Procédé De Préparation De Lomitapide
标题: Process For The Preparation Of Lomitapide[fr] Procédé De Préparation De Lomitapide
摘要:本发明涉及一种制备具有可接受杂质水平的高纯度洛米他派或其药用可接受盐的方法.

专利信息

专利号:US-7956214-B2
优先权日:2001-11-02
标题 :Process for the preparation of aniline-derived thyroid receptor ligands
发明人：CHIDAMBARAM RAMAKRISHNAN; KANT JOYDEEP; WEAVER RAYMOND E; YU JURONG; GHOSH ARUN
权利人:KAROBIO AB; BRISTOL MYERS SQUIBB CO
摘要:Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.

专利号:US-2015139987-A1
优先权日:2013-11-20
标 题 :Treatment of homozygous familial hypercholesterolemia
发明人：MARTIN ROBERT L; MCWHERTER CHARLES A; O'MARA PATRICK J
权利人:CYMABAY THERAPEUTICS INC
摘要:Treatment of homozygous familial hypercholesterolemia by administration of (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof, optionally in combination with an MTP inhibitor, an apoB-100 synthesis inhibitor, or a PCSK9 inhibitor.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:US-9198917-B2
优先权日:2012-12-11
标题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; DAVOREN JENNIFER ELIZABETH; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure n nwherein the variables R 1 , R 2 , R 3 , R 4 and x are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.