CAS: 167933-07-5; 2H-Benzimidazol-2-One, 1,3-Dihydro-1-[2-[4-[3-(Trifluoromethyl)Phenyl]-1-Piperazinyl]Ethyl]-

上下游产品

3-bromo-1-trifluoromethylbenzene 1-(prop-1-en-2-yl)-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one 1,2-diamino-benzene 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one

1,3-二氢-1-(2-羟基乙基)-3-(1-甲基乙烯基)-2H-苯并咪唑-2-酮置于溶剂黄146,三乙胺体系中,用 二氯甲烷,水,乙酸乙酯 用作溶剂,化学反应 36.5H,反应生成氟立班丝氨
参考文献:一种制备氟班色林的新工艺
标题:一种制备氟班色林的新工艺
摘要:本发明公开了一种制备氟班色林的新工艺.以1‑异丙烯基‑2‑苯并咪唑酮为原料,先与2‑溴乙醇反应,生成中间体1,中间体1再与甲磺酰氯反应生成中间体2,中间体2在催化剂存在下与1‑(3‑三氟甲基苯基)哌嗪盐反应生成中间体3,中间体3脱保护基得到氟班色林.

专利信息

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:US-2008269233-A1
优先权日:2005-08-04
标 题:Piperidinoyl-Pyrrolidine and Piperidinoyl-Piperidine Compounds
发明人：ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN
权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN
摘要:The present invention relates to a class of compounds of general formula (I) n n n n n n n n n n and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R 6 , R 7 and R 10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

专利号:US-8138188-B2
优先权日:2006-02-23
标题 :Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
发明人：ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM
权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM; PFIZER
摘要:The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) n nwherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

专利号:CN-114085197-B
优先权日:2021-12-01
标题:4-(3-Trifluoromethylphenyl)-1-piperazine-ethanol, flibanserin intermediates, and synthesis methods of flibanserin