📜N-苯甲酰基-L-精氨酸乙酯盐酸盐置于l-1,4-二硫代苏糖醇,水,Papain体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 0.08H,反应生成N-Alpha-苄酰-L-精氨酸 参考文献:Synthesis Of Papain-polyacrylamide Hydrogel Microspheres And Their Catalytic Application 标题:Synthesis Of Papain-polyacrylamide Hydrogel Microspheres And Their Catalytic Application 摘要:一个形成木瓜蛋白酶-Pahms的过程示意图. Doi:10.1039/d1Nj02551A
专利号:US-7192730-B2 优先权日:1996-12-23 标 题:Thermostable proteolytic enzymes and uses thereof in peptide and protein synthesis 发明人:YOUNG DAVID MICHAEL 权利人:UNIV FLORIDA 摘要:The subject invention pertains to new thermostable enzymes and the use of these enzymes both in proteolysis as well as protein and polypeptide synthesis. The subject invention further concerns polynucleotide sequences which encode the enzymes of the subject invention.
专利号:WO-8900428-A1 优先权日:1987-07-17 标 题:Use of atrial peptide antibodies, receptor antagonists, and atrial peptide synthesis inhibitors in controlling renal and systemic vasodilation in diabetes mellitus 发明人:BRENNER BARRY M; BALLERMANN BARBARA J 权利人:BRIGHAM & WOMENS HOSPITAL 摘要:The invention relates to a method of treating diabetes-induced microangiopathy, glomerular hyperfiltration, glomerulopathy, and renal and systemic vasodilation in an animal by administration of a compound selected from the group consisting of anti-ANP antibodies, ANP receptor antagonists and ANP synthesis inhibitors.
专利号:US-10669306-B2 优先权日:2016-02-04 标题:Solid supports for use in solid-phase peptide synthesis, kits, and related methods 发明人:CHATTERJEE CHAMPAK; SHELTON PATRICK M; WELLER CAROLINE E 权利人:UNIV WASHINGTON 摘要:Solid supports for use in solid-phase peptide synthesis (SPPS) are provided. The solid supports may include a resin and a protected linker coupled to the resin. The linker may be an N-mercaptoethoxyglycine, an N-mercaptopropoxyglycine, an N-mercaptobutoxyglycine, and/or another suitable linker. Kits for use in SPPS are also provided. The kits may include a solid support, a solution including a thiol or a selenol, one or more pluralities of protected amino acids, and/or a wash buffer. Methods of SPPS are also provided. The methods may include providing a solid support including a resin coupled to a protected linker.
专利号:WO-2006097348-A1 优先权日:2005-03-15 标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips 发明人:CALS-GRIERSON MARIE-MADELEINE 权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE 摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .
专利号:EP-2153815-A1 优先权日:2008-08-05 标题 :Use of urea containing compositions 发明人:TRULLAS CABANAS CARLOS RAMON; KRUTMANN JEAN PROF DR 权利人:ISDIN SA 摘要:The present invention relates to the use of a composition comprising urea for increasing the expression of at least one gene associated with the collagen synthesis within the dermis of the skin. nThe urea composition has been used for preventing/treating damages of the skin such as signs of aging, wrinkles, damages associated with UV-radiation, wounds, skin diseases.
专利号:US-5659061-A 优先权日:1995-04-20 标 题:Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities 发明人:GLAZIER ARNOLD 权利人:DRUG INNOVATION & DESIGN INC 摘要:The composition, synthesis, and applications of tumor associated protease activated prodrugs of phosphoramide mustard, isophosphoramide mustard and analogs with detoxification functionalities are described. These drugs release a cytotoxic phosphoramide mustard analog following activation by tumor associated proteases and esterases. The general structure for these drugs is: ##STR1## Wherein R1 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; wherein X is a good leaving group such as a halogen; R2 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; or an amino group (NH 2 ) which may optionally be substituted. Wherein A is a benzyloxy derivative with one or more acyloxy or acylamino groups in para or ortho portions relative to the phosphoester; and wherein the acyloxy or acylamino groups are not (substituted or unsubstituted) p-guanidino-benzoyloxy groups or p-guanidino-benzoylamino groups.
参考标题:Synthetic Approaches To A Challenging And Unusual Structure-An Amino-Pyrrolidine Guanine Core 作者:Rafael Rippel,Luís Pinheiro,Mónica Lopes,Ana Lourenço,Luísa M. Ferreira,Paula S. Branco 摘要:The Synthesis Of An Unreported 2-Aminopyrrolidine-1-Carboxamidine Unit Is Here Described For The First Time. This Unusual And Promising Structure Was Attained Through The Oxidative Decarboxylation Of Amino Acids Using The Pair Of Reagents, Silver(I)/peroxydisulfate (Ag(I)/s2O82−) Followed By Intermolecular (In The Case Of L-Proline Derivative) And Intramolecular Trapping (In The Case Of Acyl L-Arginine)
合成参考文献
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