CAS: 154-92-7; Benzoyl-L-Arginine

该化合物是属于氨基酸衍生物类的合成化合物,其特征是存在氨基氨酸基酸碱,经过添加苯并酰组加以修改,这种改变会增加其亲脂性,并影响其生物活动.该化合物一般是白色的,白色的,脱白的晶体粉,在有机溶剂中溶解,但水溶解性有限. 苯并酰-L-arginine经常用于生物化学研究和药物应用中,特别是在有关酶抑制的研究中和作为各种酶反应的子体方面,其结构特征允许它与生物系统互动,使其成为蛋白相互作用和代谢途径研究的宝贵工具.安全数据表明,与许多化学物质一样,应谨慎处理,并遵循适当的安全议定书,以减轻任何潜在危害.

结构式图片

相似化合物

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合成工艺路线路线简述

    📜N-苯甲酰基-L-精氨酸乙酯盐酸盐置于l-1,4-二硫代苏糖醇,水,Papain体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 0.08H,反应生成N-Alpha-苄酰-L-精氨酸
    参考文献:Synthesis Of Papain-polyacrylamide Hydrogel Microspheres And Their Catalytic Application
    标题:Synthesis Of Papain-polyacrylamide Hydrogel Microspheres And Their Catalytic Application
    摘要:一个形成木瓜蛋白酶-Pahms的过程示意图.
    Doi:10.1039/d1Nj02551A

    海关参考信息

    专利信息


    专利号:US-7192730-B2
    优先权日:1996-12-23
    标 题:Thermostable proteolytic enzymes and uses thereof in peptide and protein synthesis
    发明人:YOUNG DAVID MICHAEL
    权利人:UNIV FLORIDA
    摘要:The subject invention pertains to new thermostable enzymes and the use of these enzymes both in proteolysis as well as protein and polypeptide synthesis. The subject invention further concerns polynucleotide sequences which encode the enzymes of the subject invention.

    专利号:WO-8900428-A1
    优先权日:1987-07-17
    标 题:Use of atrial peptide antibodies, receptor antagonists, and atrial peptide synthesis inhibitors in controlling renal and systemic vasodilation in diabetes mellitus
    发明人:BRENNER BARRY M; BALLERMANN BARBARA J
    权利人:BRIGHAM & WOMENS HOSPITAL
    摘要:The invention relates to a method of treating diabetes-induced microangiopathy, glomerular hyperfiltration, glomerulopathy, and renal and systemic vasodilation in an animal by administration of a compound selected from the group consisting of anti-ANP antibodies, ANP receptor antagonists and ANP synthesis inhibitors.

    专利号:US-10669306-B2
    优先权日:2016-02-04
    标题:Solid supports for use in solid-phase peptide synthesis, kits, and related methods
    发明人:CHATTERJEE CHAMPAK; SHELTON PATRICK M; WELLER CAROLINE E
    权利人:UNIV WASHINGTON
    摘要:Solid supports for use in solid-phase peptide synthesis (SPPS) are provided. The solid supports may include a resin and a protected linker coupled to the resin. The linker may be an N-mercaptoethoxyglycine, an N-mercaptopropoxyglycine, an N-mercaptobutoxyglycine, and/or another suitable linker. Kits for use in SPPS are also provided. The kits may include a solid support, a solution including a thiol or a selenol, one or more pluralities of protected amino acids, and/or a wash buffer. Methods of SPPS are also provided. The methods may include providing a solid support including a resin coupled to a protected linker.

    专利号:WO-2006097348-A1
    优先权日:2005-03-15
    标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
    发明人:CALS-GRIERSON MARIE-MADELEINE
    权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
    摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .

    专利号:EP-2153815-A1
    优先权日:2008-08-05
    标题 :Use of urea containing compositions
    发明人:TRULLAS CABANAS CARLOS RAMON; KRUTMANN JEAN PROF DR
    权利人:ISDIN SA
    摘要:The present invention relates to the use of a composition comprising urea for increasing the expression of at least one gene associated with the collagen synthesis within the dermis of the skin. nThe urea composition has been used for preventing/treating damages of the skin such as signs of aging, wrinkles, damages associated with UV-radiation, wounds, skin diseases.

    专利号:US-5659061-A
    优先权日:1995-04-20
    标 题:Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities
    发明人:GLAZIER ARNOLD
    权利人:DRUG INNOVATION & DESIGN INC
    摘要:The composition, synthesis, and applications of tumor associated protease activated prodrugs of phosphoramide mustard, isophosphoramide mustard and analogs with detoxification functionalities are described. These drugs release a cytotoxic phosphoramide mustard analog following activation by tumor associated proteases and esterases. The general structure for these drugs is: ##STR1## Wherein R1 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; wherein X is a good leaving group such as a halogen; R2 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; or an amino group (NH 2 ) which may optionally be substituted. Wherein A is a benzyloxy derivative with one or more acyloxy or acylamino groups in para or ortho portions relative to the phosphoester; and wherein the acyloxy or acylamino groups are not (substituted or unsubstituted) p-guanidino-benzoyloxy groups or p-guanidino-benzoylamino groups.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Synthetic Approaches To A Challenging And Unusual Structure-An Amino-Pyrrolidine Guanine Core
    作者:Rafael Rippel,Luís Pinheiro,Mónica Lopes,Ana Lourenço,Luísa M. Ferreira,Paula S. Branco
    摘要:The Synthesis Of An Unreported 2-Aminopyrrolidine-1-Carboxamidine Unit Is Here Described For The First Time. This Unusual And Promising Structure Was Attained Through The Oxidative Decarboxylation Of Amino Acids Using The Pair Of Reagents, Silver(I)/peroxydisulfate (Ag(I)/s2O82−) Followed By Intermolecular (In The Case Of L-Proline Derivative) And Intramolecular Trapping (In The Case Of Acyl L-Arginine)

    合成参考文献


    摘要:G. W. Schwert and Y. Takenaka, Biochim. Biophys. Acta 16, 570 (1955).
    摘要:J. R. Whitaker and M. L. Bender, J. Am. Chem. Soc. 87, 2728 (1965).
    摘要:L. A. A. E. Sluyterman, Biochim. Biophys. Acta 85, 305 (1964).
    参考文献:10.1016/j.bmcl.2012.11.102
    摘要:Bozdag M, Dreker T, Henry C, Tosco P, Vallaro M, Fruttero R, Scozzafava A, Carta F, Supuran CT. Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors. Bioorganic & Medicinal Chemistry Letters. 2013 Feb;23(3):715–9. doi: 10.1016/j.bmcl.2012.11.102.
    参考文献:10.1007/s13197-011-0608-5
    摘要:Xiao J, Zhang H. Comparative evaluation of Jatropha curcas L. seed meals obtained by different methods of defatting on toxic, antinutritional and nutritive factors. Journal of Food Science and Technology. 2011 Dec 24;51(6):1126–32. doi: 10.1007/s13197-011-0608-5.
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