CAS: 14437-03-7; Methyl Tosylcarbamate

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16066-84-5 4248-19-5 51779-32-9

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CAS号67-56-1 甲醇 | CAS号4083-64-1 对甲基苯磺酰异氰酸酯 | CAS号70-55-3 对甲苯磺酰胺 | CAS号79-22-1 氯甲酸甲酯 | CAS号5219-81-8 1,3-bis-(4-meth... | CAS号616-38-6 碳酸二甲酯 | CAS号4083-64-1 对甲基苯磺酰异氰酸酯

📜Methyl N-(4-Methylphenyl)Sulfonyl-N-Nitrocarbamate置于水体系中,化学反应 2.0H,以100%的收率获得甲苯磺酰氨基甲酸甲酯
参考文献:The Chemistry Of Nitroimides. 2. Hydrolysis And Alcoholysis Of Nitromides
标题:The Chemistry Of Nitroimides. 2. Hydrolysis And Alcoholysis Of Nitromides
摘要:
Doi:10.1007/bf01094641

专利信息

专利号:US-2025049736-A1
优先权日:2021-12-16
标 题 :Sulfonamide derivatives and their use as soluble epoxide hydrolase inhibitors
发明人：IYER MALLIGA R; KUNDU BISWAJIT
权利人:THE US SECRETARY DEPARTMENT OF HEALTH
摘要:The present invention relates to compounds of formulae I and II. The compounds are useful for treating hypertension, atherosclerosis, pulmonary diseases, diabetes, pain, fibrosis, addictive disorders, inflammation, and immunological disorders or a condition treatable or preventable by inhibition of soluble epoxide hydrolase. Preferred compounds are N-((adamantan-1-yl)carbamoyl)-benzenesulfonamide derivatives. Exemplary compounds are e.g. •N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)-4-methylbenzenesulfonamide (example 14, compound 4a) •4-(tert-butyl)-N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)benzenesulfonamide (example 15, compound 4b) •N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)-4-(trifluoromethyl)benzenesulfonamide (example 16, compound 4j). The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof.