CAS: 14321-27-8; N-Benzylethanamine

相似化合物

103-49-1 354-38-1 5824-40-8

上下游产品

CAS号588-46-5 N-乙酰苄胺 | CAS号6852-54-6 N-亚苄基乙胺 | CAS号34233-75-5 Benzylethylenimine | CAS号100-52-7 苯甲醛 | CAS号75-04-7 乙胺 | CAS号75-03-6 碘乙烷 | CAS号100-46-9 苄胺 | CAS号109-89-7 二乙胺 | CAS号103-49-1 二苄胺 | CAS号218900-28-8 tert-butyl N-be... | CAS号20689-96-7 N-NITROSO-N-ETH... | CAS号121-44-8 三乙胺 | CAS号108-88-3 甲苯 | CAS号883-93-2 2-苯基苯并噻唑 | CAS号6852-54-6 N-亚苄基乙胺 | CAS号780-25-6 N-亚苄基苄胺 | CAS号100-52-7 苯甲醛

N,N-二乙基苄胺置于palladium On Activated Charcoal 氧气体系中,用 甲醇 用作溶剂,化学反应 24.0H,反应生成N-乙基苄胺
参考文献:Chaudhuri,Naba K.; Servando,Ofelia; Markus,Bohdan,Journal Of The Indian Chemical Society,1985,Vol. 62,# 11,P. 899-903
标题:Chaudhuri,Naba K.; Servando,Ofelia; Markus,Bohdan,Journal Of The Indian Chemical Society,1985,Vol. 62,# 11,P. 899-903

专利信息

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-6919382-B2
优先权日:2000-08-31
标 题 :Preparation and uses of conjugated solid supports for boronic acids
发明人：HALL DENNIS G
权利人:UNIV ALBERTA
摘要:The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.

专利号:US-4701499-A
优先权日:1983-10-24
标题:Synthesis of N-substituted peptide amides
发明人：KORNREICH WAYNE D; ANDERSON HARRY A; PORTER JOHN S; RIVIER JEAN E F
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:Peptide N-alkylamides, and other C-terminal N-substituted amides, can be synthesized using solid-phase synthesis on a benzene-containing resin which is suitably methylated. Reactive amino groups are attached directly or indirectly to the methyl groups, for example, such as by reacting commercially available chloromethylated polystyrene resins with an alkylamine to create a resin-amine. The C-terminal amino acid of the desired peptide is linked to the resin-amine via an amide linkage, and the peptide is thereafter built in normal fashion. Treatment of the completed peptide intermediate with HF is effective to both effect deprotection and cleave the peptide from the resin in the form of the N-substituted amide. Examples include peptide N-ethylamides, N-fluoroethylamide, N-anilides and other substituted N-benzylamides.

专利号:US-4569967-A
优先权日:1983-10-24
标 题 :Synthesis of N-substituted peptide amides
发明人：KORNREICH WAYNE D; ANDERSON HARRY A; PORTER JOHN S; RIVIER JEAN E F
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:Peptide N-alkylamides, and other C-terminal N-substituted amides, can be synthesized using solid-phase synthesis on a benzene-containing resin which is suitably methylated. Reactive amino groups are attached directly or indirectly to the methyl groups, for example, such as by reacting commercially available chloromethylated polystyrene resins with an alkylamine to create a resin-amine. The C-terminal amino acid of the desired peptide is linked to the resin-amine via an amide linkage, and the peptide is thereafter built in normal fashion. Treatment of the completed peptide intermediate with HF is effective to both effect deprotection and cleave the peptide from the resin in the form of the N-substituted amide. Examples include peptide N-ethylamides, N-fluoroethylamide, N-anilides and other substituted N-benzylamides.

专利号:US-7105666-B2
优先权日:2002-06-27
标 题:Synthesis of purine derivatives
发明人：HAMMARSTROEM LARS G J; KRAUSS NANCY ELISABTH; LABADIE SHARADA SHENVI; SMITH DAVID BERNARD; TALAMAS FRANCISCO XAVIER
权利人:ROCHE PALO ALTO LLC
摘要:The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positions, displacement of an alkylsulfony group at the 2-position of the pyrimidine, reduction of the nitro group and formation of the imidazole portion of the purine compound. Furthermore, the methods of the present invention are ideally suited to the preparation of a library of purine compounds.