CAS: 143071-78-7; 6-(4-Fluorophenoxy)-3-Pyridinamine

该化合物是一种氟芳烃衍生物,其特点是六点方位的核心和一个四氟苯氧组在三点的矿组以四氟苯氧组取代.该化合物是制药和农用化学合成的多种中间体,特别是在开发生物活性分子方面.其结构动力将富电和缺电的芳香系统结合起来,增强了其在交叉相交反应和作为热循环框架的建筑块的效用.氟的替代提高了代谢稳定性和目标应用中的结合性.高纯度和定义明确的再活性使得它对于需要精确功能化的研究和工业应用具有价值.

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25194-67-6 77006-26-9 31011-28-6

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上下游产品

2-(4-fluorophenoxy)-5-nitropyridine 6-(4-fluorophenoxy)pyridin-3-ol

合成工艺路线路线简述

    📜2-(4-氟-苯氧基)-5-硝基-吡啶 反应生成6-(4-氟苯氧基)-3-氨基吡啶
    参考文献:Potent,Selective Spiropyrrolidine Pyrimidinetrione Inhibitors Of Mmp-13
    标题:Potent,Selective Spiropyrrolidine Pyrimidinetrione Inhibitors Of Mmp-13
    摘要:Explorations In The Pyrimidinetrione Series Of Mmp-13 Inhibitors Led To The Discovery Of A Series Of Spiro-Fused Compounds That Are Potent And Selective Inhibitiors Of Mmp-13. While Other Spiro-Fused Motifs Are Hydrolytically Unstable,Presumably Due To Electronic Destabilization Of The Pyrimidinetrione Ring,The Spiropyrrolidine Series Does Not Share This Liability. Greater Than 100-Fold Selectivity Versus Other Mmp Family Members Was Achieved By Incorporation Of An Extended Aryl-Heteroaryl P1' Group. When Dosed As The Sodium Salt,These Compounds Displayed Excellent Oral Absorption And Pharmacokinetic Properties. Despite The Selectivity,A Representative Of This Series Produced Fibroplasia In A 14 Day Rat Study. (C) 2007 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmcl.2007.09.085

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    参考文献:10.1016/j.bbrc.2023.08.050
    摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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