CAS: 120373-24-2; Isopropyl Unoprostone

上下游产品

(5Z)-7-((1R,2R,3R,5S)-3,5-二羟基-2-(3-氧代癸基)环戊基)-5-庚烯酸异丙酯 Unoprostone 120373-36-6

(Z)-7-[(1R,2R,3R,5S)-2-(3-(Tert-Butyldimethyl-Silyloxy)Decyl)-5-Hydroxy-3-(Tetrahydro-2H-Pyran-2-Yloxy)Cyclopentyl]Hept-5-Enoic Acid置于sodium Chloride Dihydrate,2,2,6,6-四甲基哌啶氧化物,2,2'-二硫二吡啶,四丁基氟化铵,水,碳酸氢钠,Potassium Carbonate,对甲苯磺酸,三苯基膦,Potassium Bromide,Potassium Hydroxide体系中,用 四氢呋喃,甲醇,5,5-Dimethyl-1,3-Cyclohexadiene,水,N,N-二甲基甲酰胺,异丙醇,甲苯 用作溶剂,化学反应 29.0H,反应生成异丙基乌诺前列酮
参考文献:Processes And Intermediates For The Preparations Of Isomer Free Prostaglandins
标题:Processes And Intermediates For The Preparations Of Isomer Free Prostaglandins
摘要:提供了一种用于制备基本上不含5,6-顺式异构体的化合物i-2的新工艺:其中r2,R3和r4如规范中定义.还提供了用于制备无异构体前列腺素及其衍生物的新中间体.

专利信息

专利号:US-10100028-B2
优先权日:2013-09-30
标 题:Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis
发明人：YIANNIKOUROS GEORGE PETROS; KALARITIS PANOS; GAMAGE CHAMINDA PRIYAPUSHPA; AREFYEV DENIS VIKTOROVICH
权利人:IRIX PHARMACEUTICALS INC; PATHEON API SERVICES INC
摘要:Methods of synthesizing prostaglandins, prostaglandin analogs and their synthetic intermediates are described. The methods can comprise metal-catalyzed metathesis reactions. Also provided are synthetic intermediates that can be used in the synthesis of the prostaglandins and prostaglandin analogs.

专利号:US-6359001-B1
优先权日:1997-04-22
标 题 :Use of α-methyl-p-tyrosine to inhibit melanin production in iris melanocytes
发明人：DRAGO FILIPPO
权利人:PHARMACIA AB
摘要:The use of agents for blocking the synthesis of tyrosinase to prevent permanent pigmentation of the iris caused by melanin deposit induced by pharmacological treatments or by metabolic imbalance is described.

专利号:US-6646001-B2
优先权日:1997-12-19
标 题 :Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
发明人：HELLBERG MARK R; NIXON JON C
权利人:ALCON MFG LTD
摘要:Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin FP receptor agonist and a prostaglandin synthesis inhibitor.

专利号:WO-0195913-A1
优先权日:2000-06-13
标 题:Methods and compositions for the prevention of myopia
发明人：STJERNSCHANTZ JOHAN; RESUL BAHRAM
权利人:SYNPHORA AB; STJERNSCHANTZ JOHAN; RESUL BAHRAM
摘要:Exogenous prostaglandins and derivatives of prostaglandins as well as anti-inflammatory agents blocking prostaglandin synthesis are disclosed as useful for the prevention of the development of myopia. The prostaglandins should preferentially be administered topically on the eye, whereas the anti-inflammatory agents may be administered topically on the eye or orally. The administration may be continuous or intermittent.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:BR-112016006951-B1
优先权日:2013-09-30
标 题 :NEW SYNTHESIS PATHWAYS FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES WITH THE USE OF METATHESIS