CAS: 1194-22-5; 6-Hydroxy-2-Methylpyrimidin-4(3H)-One

相似化合物

1197-04-2 1480-98-4 929903-21-9

上下游产品

CAS号124-42-5 乙脒盐酸盐 | CAS号105-53-3 丙二酸二乙酯 | CAS号145250-81-3 2,2-dinitroethe... | CAS号32617-22-4 potassium,dinit... | CAS号183473-19-0 2-methyl-4,6-bi... | CAS号14160-91-9 2-甲基-4,6-二氯嘧啶-5-甲醛 | CAS号13162-43-1 2-甲基-4,6-二氯-5-硝基嘧啶 | CAS号1780-26-3 4,6-二氯-2-甲基嘧啶 | CAS号374552-65-5 2-(dinitromethy... | CAS号76574-35-1 4-amino-6-metho... | CAS号76574-36-2 2-甲基-4,6-二氯嘧啶-5-甲腈 | CAS号76574-37-3 2-甲基-4-氨基-6-氯嘧啶-5-甲腈

盐酸乙脒,丙二酸二乙酯置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 3.0H,以91.2%的收率获得2-甲基-4,6-二羟基嘧啶
参考文献:An Efficient And Convenient Synthesis Of 4,6-Dichloro-2-Methyl-5-Nitropy
标题:An Efficient And Convenient Synthesis Of 4,6-Dichloro-2-Methyl-5-Nitropy
摘要:在甲醇钠存在下,通过盐酸乙脒和丙二酸二乙酯的环化反应,可以方便地合成 4,6-二氢-2-甲基嘧啶,收率为 91.2%.4,6-二氢-2-甲基-5-硝基嘧啶可以在硝酸,三氯乙酸和乙酸的混合酸中进行硝化反应,收率为 88.3%,然后使用三氯氧磷进行氯化反应,可以得到 4,6-二氯-2-甲基-5-硝基嘧啶,收率为 82.6%.
Doi:10.14233/ajchem.2014.16338

专利信息

专利号:US-10981850-B2
优先权日:2019-04-15
标 题 :One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives
发明人：PORCO JOHN A; BEELER AARON B; BROWN LAUREN E; TRILLES RICHARD V
权利人:UNIV BOSTON
摘要:Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.

专利号:US-8158788-B2
优先权日:2008-09-30
标 题:Method for the nitration of 4,6-dihydroxy-2-methylpyrimidine
发明人：GOH EUN MEE; KIM JIN SEUK; CHO JIN RAI; KIM HYOUN-SOO
权利人:GOH EUN MEE; KIM JIN SEUK; CHO JIN RAI; KIM HYOUN-SOO; AGENCY DEFENSE DEV
摘要:Disclosed is a method for the nitration of 4,6-dihydroxy-2-methylpyrimidine for the synthesis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine which is used as a precursor of 1,1-diamino-2,2-dinitroethylene, one type of explosives. The present invention provides an improved method for the nitration of 4,6-dihydroxy-2-methylpyrimidine, wherein organic solvent is applied in the nitration process of 4,6-dihydroxy-2-methylpyrimidine thereby solving the safety problem while improving the yield of nitration.

专利号:US-5596001-A
优先权日:1993-10-25
标题 :4-aryl-3-(heteroarylureido)quinoline derivatves
发明人：HAMANAKA ERNEST S
权利人:PFIZER
摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.

专利号:EP-3263548-B1
优先权日:2016-06-29
标题 :Method for the synthesis of 1,1-diamino-2,2-dinitroethylene (fox-7) or a salt thereof

专利号:US-2021163387-A1
优先权日:2019-04-15
标题:One-step flow-mediated synthesis of cannabidiol (cbd) and derivatives

专利号:US-2020325091-A1
优先权日:2019-04-15
标题:One-step flow-mediated synthesis of cannabidiol (cbd) and derivatives