CAS: 110-00-9; Furan

该化合物是一种由五人组成的芳香环,含有4个碳原子和一个氧原子,其分子式为C4H4O,以其独特的甜味,类似乙醚的气味而著称.Furan是一种在室温下无色液体,具有高度挥发性.它溶于水和有机溶剂中,具有多种化学反应的特性.Furan以其再活动性而著称,特别是因为它含有氧原子,可以参与电益替代反应.它可以发生聚合,并经常被用作各种化学品合成的建筑块,包括制药和农用化学品.然而,Furan也被认为是潜在的致癌物,引起处理和接触方面的安全问题.它存在于食物产品中,特别是热化或加工食品中,由于其毒理学影响而成为研究的对象.

结构式图片

物理性质

欧盟法规

统一分类与标签压力设备指令-第1组危险流体REACH注册ECHA物质欧盟气雾剂指令-标签制度食品接触材料-禁用CMR物质C&L通报REACH预注册废弃物危险特性清单ECHA物质工作场所安全标识要求化妆品禁用物质清单欧盟候选物质清单

上下游产品

CAS号106-99-0 丁二烯 | CAS号20842-02-8 potassium,furan... | CAS号98-01-1 糠醛 | CAS号527-69-5 糠酰氯 | CAS号82660-72-8 2',6'-exo-spiro... | CAS号584-12-3 2-溴呋喃 | CAS号88-14-2 糠酸; 2-糠酸; 2-呋喃甲酸 | CAS号82660-71-7 2',6'-exo-spiro... | CAS号20485-44-3 2,3-Diamino-2,3... | CAS号106750-88-3 1,4-Epoxynaphth... | CAS号111252-81-4 3-(furan-2-yl)-... | CAS号105949-21-1 6-chloro-8-prop... | CAS号105949-23-3 6-chloro-11,11-... | CAS号35461-98-4 4-(2-呋喃)苯甲酸 | CAS号65007-00-3 三氟甲基磺酸-2-吡啶基酯 | CAS号372-48-5 2-氟吡啶 | CAS号55484-03-2 2-(furan-2-yl)p... | CAS号6068-62-8 反式丁烯二酸双(二甲基羧醛)

合成工艺路线路线简述

  • 合成目标产物 Furan 主要起始原料 Furfural
  • (文献来源)合成步骤主要原料 Furfural
Cantharidin置于palladium Asbestos体系中,化学反应生成呋喃
参考文献:V. Bruchhausen; Bersch,Archiv Der Pharmazie,1928,P. 701
标题:V. Bruchhausen; Bersch,Archiv Der Pharmazie,1928,P. 701

专利信息


专利号:US-2020148541-A1
优先权日:2017-06-01
标题 :An approach to a bottom-up synthesis of nanocarbons
发明人:GIDRON ORI; PHATANGARE SUNITA; DISHI OR; BEDI ANJAN
权利人:YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:Provided is a method for the synthesis of a Ï€-conjugated system from oligofurans, under conditions involving cycloaddition.

专利号:US-3872168-A
优先权日:1972-10-02
标题:Synthesis of acids and amides
发明人:COLLMAN JAMES P; WINTER STANLEY R; KOMOTO ROBERT G
权利人:TRUSTEES OF THE LELAND STAMFOR
摘要:Synthesis of acids R1COOH and amides R1CONR2R3 wherein R1 is attached to the carbonyl group by an aliphatic carbon atom and R2 and R3 are hydrogen or organic groups of a primary or secondary amine, by forming an alkyl or acyl intermediate (R1Fe(CO) 4 or R1COFe(CO) 4) and treating the intermediate with a suitable cleaving agent and, in the case of amides, also with ammonia or an amine.

专利号:US-7160517-B2
优先权日:2000-08-18
标题 :Apparatus and methods for the automated synthesis of oligosaccharides
发明人:SEEBERGER PETER H; PLANTE OBADIAH J
权利人:MASSACHUSETTS INST OF TECHNOLG
摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

专利号:US-2024409495-A1
优先权日:2021-10-20
标 题 :Process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts
发明人:JAISANKAR PARASURAMAN; DEB INDUBHUSAN; BHATTACHARJEE PINAKI
权利人:COUNCIL SCIENT IND RES
摘要:Methods involving preparation of building blocks of 2,7-dihydroxy-9-fluorenone toward the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, phosphate, tartrate, triflate, trifluoroacetate, tetrafluoroborate) of tilorone, and an efficient, safe, cost effective method for the preparation of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 and its various salts are developed. The methods involve oxygenation of fluorene, nitration of fluorenone, followed by reduction and diazotization toward the formation of 2,7-dihydroxy-9-fluorenone, which is the key intermediate for the formation of 2,7-bis-[2-(diethylamino)ethoxy]-9-fluorenone-dihydrochloride (Tilorone dihydrochloride) and other tilorone salts. The synthesis method has relatively simple operation, mild reaction conditions, high yield, and simple process with yields of 80-97%. Subsequent product purification of this method uses filtration and crystallization methods, avoiding the existing methods of column chromatography. Therefore, the research of its synthetic method being with a wide range of applications from the drug development and material synthesis point of view.

专利号:US-10450201-B2
优先权日:2017-10-04
标题 :Method for the synthesis of nanoparticles of heterometallic nanocomposite materials
发明人:SOHAIL MANZAR; SHARIF MUHAMMAD; KHAN SAFYAN A; SHER MUHAMMAD; JAGADEESH RAJENAHALLY V
权利人:UNIV KING FAHD PET & MINERALS
摘要:A simple one pot sol-gel method for the synthesis of bi-metal nanostructures is based on non-noble metals (Fe, Co and Sn) and titanium. The method involves the synthesis of mixed metal nanoscale composites using low cost precursors which allow for the synthesis of desired nanocomposite materials with self-scarifying titanium or silica supports. The procedure does not require any surfactant or any need for pH controlled step. Applicants' method involves the in-situ generation of precursors and their simultaneous entrapment in a gel. This simple one pot synthesis allows for the synthesis of homogenous size, shape and distribution of targeted nanostructures. Further, this method can be applied for the preparation of various nanocomposite materials using different choices of metals and self-scarifying supports. Applicants also show that Pd, the noble metal based nanocomposite is feasible.

专利号:EP-2070941-A1
优先权日:2007-12-14
标 题 :Stereoselective synthesis of selective estrogen receptor down-regulators
权利人:BAYER SCHERING PHARMA AG; ASTRAZENECA AB
摘要:The present invention relates to stereoselective synthesis of 7-α-substituted estra-4-ene-3,17-diones. Such compounds are valuable intermediates in the synthesis of 7-α-substituted estra-1,3,5(10)-triene-3,17-diols. n Key step in this synthesis is reacting a 3-keto-4,6-estradiene with a Grignard reagent selected from the group consisting of a magnesium-halide alkyl halide having at least 3 carbon atoms, a magnesium-halide alkenyl halide having at least 3 carbon atoms, and a magnesium-halide alkynyl halide having at least 3 carbon atoms, in the presence of a catalyst system comprising CuI. n The obtained 7α-alkyl, alkenyl and alkynyl halides can be used for the synthesis of pharmaceutically actice 7-α-substituted estra-1,3,5(10)-triene-3,17-diols (antiestrogens).
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合成参考文献


参考文献:10.1007/s10529-010-0222-z
摘要:Bischoff KM, Liu S, Hughes SR, Rich JO. Fermentation of corn fiber hydrolysate to lactic acid by the moderate thermophile Bacillus coagulans. Biotechnol Lett. 2010 Jun;32(6):823–8. doi: 10.1007/s10529-010-0222-z.
参考文献:10.1080/19440040903317505
摘要:Guenther H, Hoenicke K, Biesterveld S, Gerhard-Rieben E, Lantz I. Furan in coffee: pilot studies on formation during roasting and losses during production steps and consumer handling. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Mar;27(3):283–90. doi: 10.1080/19440040903317505.
参考文献:10.1021/jp911602k
摘要:Li X, Paldus J. A multireference coupled-cluster study of electronic excitations in furan and pyrrole. J Phys Chem A. 2010 Aug 26;114(33):8591–600. doi: 10.1021/jp911602k.
参考文献:10.1016/j.biortech.2010.01.046
摘要:Kaushik G, Gopal M, Thakur IS. Evaluation of performance and community dynamics of microorganisms during treatment of distillery spent wash in a three stage bioreactor. Bioresour Technol. 2010 Jun;101(12):4296–305. doi: 10.1016/j.biortech.2010.01.046.
参考文献:10.1007/s11030-010-9228-7
摘要:Baghernejad B, Heravi MM, Oskooie HA, Poormohammad N, Khorshidi M, Beheshtiha YSh. A novel and facile synthesis of N-cyclohexyl-benzofurans by one-pot three-component reaction. Mol Divers. 2011 Feb;15(1):245–8. doi: 10.1007/s11030-010-9228-7.
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