Cantharidin置于palladium Asbestos体系中,化学反应生成呋喃 参考文献:V. Bruchhausen; Bersch,Archiv Der Pharmazie,1928,P. 701 标题:V. Bruchhausen; Bersch,Archiv Der Pharmazie,1928,P. 701
专利信息
专利号:US-2020148541-A1 优先权日:2017-06-01 标题 :An approach to a bottom-up synthesis of nanocarbons 发明人:GIDRON ORI; PHATANGARE SUNITA; DISHI OR; BEDI ANJAN 权利人:YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD 摘要:Provided is a method for the synthesis of a Ï€-conjugated system from oligofurans, under conditions involving cycloaddition.
专利号:US-3872168-A 优先权日:1972-10-02 标题:Synthesis of acids and amides 发明人:COLLMAN JAMES P; WINTER STANLEY R; KOMOTO ROBERT G 权利人:TRUSTEES OF THE LELAND STAMFOR 摘要:Synthesis of acids R1COOH and amides R1CONR2R3 wherein R1 is attached to the carbonyl group by an aliphatic carbon atom and R2 and R3 are hydrogen or organic groups of a primary or secondary amine, by forming an alkyl or acyl intermediate (R1Fe(CO) 4 or R1COFe(CO) 4) and treating the intermediate with a suitable cleaving agent and, in the case of amides, also with ammonia or an amine.
专利号:US-7160517-B2 优先权日:2000-08-18 标题 :Apparatus and methods for the automated synthesis of oligosaccharides 发明人:SEEBERGER PETER H; PLANTE OBADIAH J 权利人:MASSACHUSETTS INST OF TECHNOLG 摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.
专利号:US-2024409495-A1 优先权日:2021-10-20 标 题 :Process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts 发明人:JAISANKAR PARASURAMAN; DEB INDUBHUSAN; BHATTACHARJEE PINAKI 权利人:COUNCIL SCIENT IND RES 摘要:Methods involving preparation of building blocks of 2,7-dihydroxy-9-fluorenone toward the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, phosphate, tartrate, triflate, trifluoroacetate, tetrafluoroborate) of tilorone, and an efficient, safe, cost effective method for the preparation of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 and its various salts are developed. The methods involve oxygenation of fluorene, nitration of fluorenone, followed by reduction and diazotization toward the formation of 2,7-dihydroxy-9-fluorenone, which is the key intermediate for the formation of 2,7-bis-[2-(diethylamino)ethoxy]-9-fluorenone-dihydrochloride (Tilorone dihydrochloride) and other tilorone salts. The synthesis method has relatively simple operation, mild reaction conditions, high yield, and simple process with yields of 80-97%. Subsequent product purification of this method uses filtration and crystallization methods, avoiding the existing methods of column chromatography. Therefore, the research of its synthetic method being with a wide range of applications from the drug development and material synthesis point of view.
专利号:US-10450201-B2 优先权日:2017-10-04 标题 :Method for the synthesis of nanoparticles of heterometallic nanocomposite materials 发明人:SOHAIL MANZAR; SHARIF MUHAMMAD; KHAN SAFYAN A; SHER MUHAMMAD; JAGADEESH RAJENAHALLY V 权利人:UNIV KING FAHD PET & MINERALS 摘要:A simple one pot sol-gel method for the synthesis of bi-metal nanostructures is based on non-noble metals (Fe, Co and Sn) and titanium. The method involves the synthesis of mixed metal nanoscale composites using low cost precursors which allow for the synthesis of desired nanocomposite materials with self-scarifying titanium or silica supports. The procedure does not require any surfactant or any need for pH controlled step. Applicants' method involves the in-situ generation of precursors and their simultaneous entrapment in a gel. This simple one pot synthesis allows for the synthesis of homogenous size, shape and distribution of targeted nanostructures. Further, this method can be applied for the preparation of various nanocomposite materials using different choices of metals and self-scarifying supports. Applicants also show that Pd, the noble metal based nanocomposite is feasible.
专利号:EP-2070941-A1 优先权日:2007-12-14 标 题 :Stereoselective synthesis of selective estrogen receptor down-regulators 权利人:BAYER SCHERING PHARMA AG; ASTRAZENECA AB 摘要:The present invention relates to stereoselective synthesis of 7-α-substituted estra-4-ene-3,17-diones. Such compounds are valuable intermediates in the synthesis of 7-α-substituted estra-1,3,5(10)-triene-3,17-diols. n Key step in this synthesis is reacting a 3-keto-4,6-estradiene with a Grignard reagent selected from the group consisting of a magnesium-halide alkyl halide having at least 3 carbon atoms, a magnesium-halide alkenyl halide having at least 3 carbon atoms, and a magnesium-halide alkynyl halide having at least 3 carbon atoms, in the presence of a catalyst system comprising CuI. n The obtained 7α-alkyl, alkenyl and alkynyl halides can be used for the synthesis of pharmaceutically actice 7-α-substituted estra-1,3,5(10)-triene-3,17-diols (antiestrogens).
参考文献:10.1007/s10529-010-0222-z 摘要:Bischoff KM, Liu S, Hughes SR, Rich JO. Fermentation of corn fiber hydrolysate to lactic acid by the moderate thermophile Bacillus coagulans. Biotechnol Lett. 2010 Jun;32(6):823–8. doi: 10.1007/s10529-010-0222-z. 参考文献:10.1080/19440040903317505 摘要:Guenther H, Hoenicke K, Biesterveld S, Gerhard-Rieben E, Lantz I. Furan in coffee: pilot studies on formation during roasting and losses during production steps and consumer handling. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Mar;27(3):283–90. doi: 10.1080/19440040903317505. 参考文献:10.1021/jp911602k 摘要:Li X, Paldus J. A multireference coupled-cluster study of electronic excitations in furan and pyrrole. J Phys Chem A. 2010 Aug 26;114(33):8591–600. doi: 10.1021/jp911602k. 参考文献:10.1016/j.biortech.2010.01.046 摘要:Kaushik G, Gopal M, Thakur IS. Evaluation of performance and community dynamics of microorganisms during treatment of distillery spent wash in a three stage bioreactor. Bioresour Technol. 2010 Jun;101(12):4296–305. doi: 10.1016/j.biortech.2010.01.046. 参考文献:10.1007/s11030-010-9228-7 摘要:Baghernejad B, Heravi MM, Oskooie HA, Poormohammad N, Khorshidi M, Beheshtiha YSh. A novel and facile synthesis of N-cyclohexyl-benzofurans by one-pot three-component reaction. Mol Divers. 2011 Feb;15(1):245–8. doi: 10.1007/s11030-010-9228-7.