CAS: 1034-10-2; Dl-Thyronine

该化合物是氨酸甲状腺素的一种合成形式,是甲状腺激素甲状腺素(T4)的衍生物,其特征是其在各种生化过程中的作用,特别是在新陈代谢和生长的调节方面.DL-Thyronine作为一种种族混合物存在,含有D-和L-enantiomers,可以展示不同的生物活动.该物质一般是白到白的晶状粉,在水和酒精中可溶解,在标准条件下结构相对稳定.在研究和临床环境中经常使用该物质研究甲状腺功能和新陈代谢.此外,DL-Thyronine可能参与其他甲状腺激素的合成,并能够影响代谢途径.其药理特性和潜在治疗用途在异性学学和代谢研究中都有意义.但是,与任何化合物一样,在使用该物质时,应考虑到与甲状腺激素有关的生理影响.

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1596-67-4 1213135-25-1 1354485-04-3

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CAS号534-51-0 3,5-二碘甲腺氨酸 | CAS号108-24-7 乙酸酐 | CAS号106-44-5 对甲酚 | CAS号35094-91-8 4-(4-甲基苯氧基)苯酚 | CAS号123-31-9 对苯二酚 | CAS号99-96-7 4-羟基苯甲酸 | CAS号7664-41-7 氨 | CAS号144-62-7 草酸

合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于磷化氢,氢碘酸体系中,化学反应生成Dl-甲状腺氨酸
    参考文献:Micropyretic Synthesis Of Nial Containing Ti And B
    标题:Micropyretic Synthesis Of Nial Containing Ti And B
    摘要:研究了添加钛和硼合金对镍铝微热合成过程和合成合金微观结构的影响.研究发现,尽管存在合金元素,但由于 Ti 和 B 之间的额外燃烧反应,四元合金的可燃性很好.还研究了合成前预热试样对合成过程的影响.研究发现,预热不仅会改变相的形态,还会影响合金中存在的相的性质.通过停止燃烧前沿和对停止燃烧前沿周围区域进行详细的微观结构表征,确定了元素粉末合成过程中两相微观结构的形成机制.
    Doi:10.1557/jmr.2000.0014

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    专利信息


    专利号:US-6080860-A
    优先权日:1992-08-31
    标 题:Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
    发明人：KARIMIAN KHASHAYAR; MURTHY KESHAVA; HALL DARREN
    权利人:BRANTFORD CHEMICALSS INC
    摘要:Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:EP-0656885-A1
    优先权日:1992-08-31
    标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor

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    [参考文献]: Kazuya Kuboyama, Et Al. Protein Tyrosine Phosphatase Receptor Type Z Negatively Regulates Oligodendrocyte Differentiation And Myelination. Plos One. 2012;7(11):E48797.
    [参考文献]: M Y Jeong, Et Al. Rubi Fructus (Rubus Coreanus) Activates The Expression Of Thermogenic Genes In Vivo And In Vitro. Int J Obes (Lond). 2015 Mar;39(3):456-64.

    合成参考文献


    参考文献:10.1007/bf00363040
    摘要:DONHOFFER S, VARNAI I, SZIEBERTH-HORVATH E. [The role of the adrenal gland in the acute action of triiodothyroacetic acid on energy transformation and body temperature of the hypophysectomized rat]. Pflugers Arch Gesamte Physiol Menschen Tiere. 1958;266(6):642–52. doi: 10.1007/bf00363040.
    参考文献:10.1007/bf03042196
    摘要:Schilling JU, Zimmermann T, Albrecht S, Zwipp H, Saeger HD. [Low T3 syndrome in multiple trauma patients--a phenomenon or important pathogenetic factor ]. Med Klin (Munich). 1999 Oct 15;94 Suppl 3():66–9. doi: 10.1007/bf03042196.
    参考文献:10.1007/bf01484311
    摘要:KOTZAUREK R. [Butanol extraction as a supplement to the Spitzy, Reese and Skrube methods of iodine determination]. Klin Wochenschr. 1960 Oct 01;38():995–7. doi: 10.1007/bf01484311.
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