CAS: 102-45-4; 1-Cyclopentyl-N-Methylpropan-2-Amine

1-环戊烯乙腈置于palladium On Activated Charcoal,甲基碘化镁,乙醚,乙醇,镍体系中,150.0 °C,13.73 Mpa 条件下,反应生成环喷他明
参考文献:Us2520015
标题:Us2520015

专利信息

专利号:US-10933028-B2
优先权日:2018-05-08
标题:Method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles
发明人：ZHANG LIPING; NI CAIHUA; LIU REN; WANG DAWEI; SHI GANG; SANG XINXIN; XIA XIAOFENG
权利人:UNIV JIANGNAN
摘要:The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(γ-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

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优先权日:2001-10-25
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