CAS: 869368-48-9; (2S,2'S)-N,N'-((2S,3S,5S)-3-Hydroxy-1,6-Diphenylhexane-2,5-Diyl)Bis(2-(3-((2-Isopropylthiazol-4-yl)Methyl)-3-Methylureido)-3-Methylbutanamide)

英文名称(2S,2'S)-N,N'-((2S,3S,5S)-3-Hydroxy-1,6-Diphenylhexane-2,5-Diyl)Bis(2-(3-((2-Isopropylthiazol-4-yl)Methyl)-3-Methylureido)-3-Methylbutanamide)
中文名称利托那韦EP杂质T
IUPAC名称(2S,2'S)-N,N'-((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamide)
其它别名Ritonavir Ep Impurity T; Ritonavir Impurity 20(Ritonavir Ep Impurity T); Ritonavir Ep Impurity T(Bp Impurity T); 2,5,10,13-Tetraazatetradecanediamide, 7-Hydroxy-N1,N14-Dimethyl-3,12-Bis(1-Methylethyl)-N1,N14-Bis[[2-(1-Methylethyl)-4-Thiazolyl]Methyl]-4,11-Dioxo-6,9-Bis(Phenylmethyl)-, (3S,6S,7S,9S,12S)-; Ritonavir Ep Imp T; Ritonavir Impurity 20; (2S)-N-[(1S,2S,4S)-1-Benzyl-2-Hydroxy-4-[[(2S)-3-Methyl-2-[[methyl[[2-(1-Methylethyl)Thiazol-4-Yl]Methyl]Carbamoyl]Amino]Butanoyl]Amino]-5-Phenylpentyl]-3-Methyl-2-[[methyl[[2-(1-Methylethyl)Thiazol-4-Yl]Methyl]Carbamoyl]Amino]Butanamide; (2S,2'S)-N,N'-((2S,3S,5S)-3-Hydroxy-1,6-Diphenylhexane-2,5-Diyl)Bis(2-(3-((2-Isopropylthiazol-4-yl)Methyl)-3-Methylureido)-3-Methylbutanamide) (Ritonavir Impurity)
CAS编号869368-48-9
FDA UNII编号:42DVW90Y6N
分子式:C46H66N8O5S2分子量:875.22
产品CID: 1873158
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: YOFGDVVGZPWCGY-JEXMNKNPSA-N
InChI=1S/C46H66N8O5S2/c1-28(2)39(51-45(58)53(9)24-35-26-60-43(48-35)30(5)6)41(56)47-34(21-32-17-13-11-14-18-32)23-38(55)37(22-33-19-15-12-16-20-33)50-42(57)40(29(3)4)52-4
计算化学: 氢键受体数9.0氢键供体数5.0可旋转键数21.0

MSDS等安全信息

警示词warning
危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

上下游产品

N-[[N-methyl-N-[(2-isopropyl-4-thiazolyl)methyl]amino]carbonyl]-L-valinyl hydroxysuccinimide ester (2S,3S,5S)-2-[N-[N-[[N-methyl-N-[(2-isopropyl-4-thiazolyl)methyl]amino]carbonyl]vanilyl]amino]-5-amino-1,6-diphenyl-3-hydroxyhexane N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine

合成工艺路线路线简述

📜(2S,3S,5S)-2-[n-[n-[[n-Methyl-N-[(2-Isopropyl-4-Thiazolyl)Methyl]Amino]Carbonyl]Vanilyl]Amino]-5-Amino-1,6-Diphenyl-3-Hydroxyhexane,N-[2-异丙基噻唑-4-甲基氨基甲酰]-L-缬氨酸置于1-羟基苯并三唑,N,N'-二环己基碳二亚胺体系中,用四氢呋喃作为反应溶剂,化学反应生成利托那韦ep杂质t
参考文献: Ritonavir Analogous Compound Useful As Retroviral Protease Inhibitor,Preparation Of The Ritonavir Analogous Compound And Pharmaceutical Composition For The Ritonavir Analogous Compound.[fr] Compose Analogue Du Ritonavir Utile Comme Inhibiteur De Protease Retroviral,Procede De Preparation De Ce Compose Et Composition Pharmaceutique Correspondante
标题: Ritonavir Analogous Compound Useful As Retroviral Protease Inhibitor,Preparation Of The Ritonavir Analogous Compound And Pharmaceutical Composition For The Ritonavir Analogous Compound.[fr] Compose Analogue Du Ritonavir Utile Comme Inhibiteur De Protease Retroviral,Procede De Preparation De Ce Compose Et Composition Pharmaceutique Correspondante
摘要:本发明描述了一种新的利托那韦类似物化合物,其在抑制hiv蛋白酶方面具有显著优越性能.本发明还描述了利用本发明的利托那韦类似物化合物或其盐,酯或前药的用途,以及在医学上使用该化合物及其制剂,特别是在治疗hiv感染方面,单独或与其他抗hiv药物联合使用.