CAS: 827-23-6; 2,4-Dibromo-6-Nitroaniline

• 英文名称2,4-Dibromo-6-Nitroaniline
• 中文名称2,4-二溴-6-硝基苯胺
• IUPAC名称2,4-dibromo-6-nitroaniline
• 其它别名2,4-二溴-6-硝苯胺; Benzenamine, 2,4-Dibromo-6-Nitro-
• CAS编号827-23-6
• MFCD编号:MFCD00012107
• EINECS号:623-304-0
• 分子式:C6H4Br2N2O2
• 分子量:295.92
• 产品CID: 1817320
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• InChIKey: OBTUHOVIVLDLLD-UHFFFAOYSA-N
• InChI=1S/C6H4Br2N2O2/c7-3-1-4(8)6(9)5(2-3)10(11)12/h1-2H,9H2…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

物理性质

• 熔点128-130 °C
• 沸点207 °C at 760 mmHg
• 闪点152.5 °C
• 密度2.177 g/cm3
• pKa:-3.25±0.25(预测)
• PSA:69.16
• LogP:2.702
• 折射率1.697
• 蒸汽压0.000188 mmHg at 25 °C
• 敏感性常温常压下稳定，避免强氧化剂接触
• 外观形态橙黄色粉末
• 储存条件请置于阴暗处, 惰性气氛中,室温

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H332 |吸入有害.
  H312 |皮肤接触有害.
  H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xn
• 安全声明26-36-36/37/39
• 危险类别码20/21/22-36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 875-51-4 = 827-23-6
  反应条件:1.1 Reagents: Bromine Solvents: Carbon Tetrachloride; 20 - 25 °C; 1 H,Rt
  标题:Effect Of Structural Factors And Solvent Nature In Bromination Of Anilines
  作者:Bagmanov,B. T.
  参考文献:Russian Journal Of Applied Chemistry 日期:2009 卷标:82(9) 页码:1570-1576]
  
  = 827-23-6
  反应条件:1.1 Reagents: Bromine Solvents: Methanol,Dichloromethane; 1 H,Rt
  标题:New Synthesis Of (+/-)-Cis-Trikentrin A Via Tandem Indole Aryne Cycloaddition/negishi Reaction. Applications To Library Development
  作者:Brown,Neil; Et Al
  参考文献:Tetrahedron Letters 日期:2009 卷标:50(51) 页码:7113-7115]
  
  = 827-23-6
  反应条件:1.1 Reagents: Sodium Bromide,Sodium Bromate Solvents: Dichloromethane,Water; 2 H,25 - 40 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 60 Min,Rt; 40 - 60 Min,Rt
  标题:Eco-Friendly And Versatile Brominating Reagent Prepared From A Liquid Bromine Precursor
  作者:Adimurthy,Subbarayappa; Et Al
  参考文献:Green Chemistry 日期:2006 卷标:8(10) 页码:916-922]
  
  875-51-4 = 827-23-6
  反应条件:1.1 Reagents: Bromine Solvents: Carbon Tetrachloride; Cooled; 20 - 25 °C; 1 H,Rt
  标题:Features Of Molecular Bromination Of Aromatic Amines
  作者:Salahov,M. S.; Et Al
  参考文献:Azerbaidzhanskii Khimicheskii Zhurnal 日期:2014 卷标:(3) 页码:22-27]
  
  = 827-23-6
  反应条件:1.1 Reagents: 2,3,5,6-Tetrabromo-4-Methyl-4-Nitro-2,5-Cyclohexadien-1-One Solvents: Trifluoroacetic Acid
  标题:Direct Nitration Of Anilines Using Nitrocyclohexadienones
  作者:Lemaire,M.; Et Al
  参考文献:Synthesis 日期:1989 卷标:(10) 页码:761-3]
  
  616-84-2 = 827-23-6
  反应条件:1.1 Solvents: Water
  标题:Halogenation. Xx. The Replacement Of Sulfonic Acid Groups By Halogens
  作者:Datta,Rasik Lal; Et Al
  参考文献:Journal Of The American Chemical Society 日期:1921 卷标:43 页码:303-15]
  
  = 827-23-6 + 875-51-4
  反应条件:1.1 Catalysts: Copper Sulfate Solvents: Acetonitrile,Water; 15 Min,25 °C1.2 Reagents: Sodium Bromide,Sodium Persulfate; 15 Min,7 °C; 2 H,7 °C; 22 H,25 °C1.3 Reagents: Sodium Hydroxide,Sodium Thiosulfate Solvents: Water; Ph 9
  标题:A Practical Procedure For Regioselective Bromination Of Anilines
  作者:Takahashi,Yusuke; Et Al
  参考文献:Synthesis 日期:2021 卷标:53(10) 页码:1828-1832]
  
  = 827-23-6 + 875-51-4
  反应条件:1.1 Reagents: Hydrogen Tribromide,Compd. With N,N-Dimethylacetamide (1:2) Solvents: Ethanol,Water
  标题:Bis(Dimethylacetamide)Hydrogen Dibromobromate: New Brominating Agent
  作者:Rodygin,M. Yu.; Et Al
  参考文献:Zhurnal Organicheskoi Khimii 日期:1992 卷标:28(9) 页码:1926-7]
  
  = 827-23-6 + 875-51-4
  反应条件:1.1 Reagents: Ammonium Bromide,Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Solvents: Methanol,Water; 4 Min,Rt1.2 Reagents: Sodium Thiosulfate Solvents: Water; Rt
  标题:Fast And Efficient Bromination Of Aromatic Compounds With Ammonium Bromide And Oxone
  作者:Naresh,Mameda; Et Al
  参考文献:Synthesis 日期:2013 卷标:45(11) 页码:1497-1504]
  
  29530-42-5 = 827-23-6 + 875-51-4 + 14227-18-0
  反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Acetic Acid,Water
  标题:Preparation Of Some 2-(Methoxyphenyl)-2H-Benzotriazoles And The Corresponding Hydroxyphenyl Compounds
  作者:Rosevear,Judi; Et Al
  参考文献:Australian Journal Of Chemistry 日期:1987 卷标:40(10) 页码:1663-73]
  
  612-29-3 = 827-23-6 + 875-51-4 + 14227-18-0
  反应条件:1.1 Solvents: Acetic Acid2.1 Reagents: Hydrogen Bromide Solvents: Acetic Acid,Water
  标题:Preparation Of Some 2-(Methoxyphenyl)-2H-Benzotriazoles And The Corresponding Hydroxyphenyl Compounds
  作者:Rosevear,Judi; Et Al
  参考文献:Australian Journal Of Chemistry 日期:1987 卷标:40(10) 页码:1663-73

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