📜三苯基膦置于lithium Aluminium Tetrahydride,水体系中,用 正丁醇 作为反应溶剂,化学反应 24.0H,反应生成 二苯基丙基膦 参考文献:Makhaev,V. D.; Borisov,A. P.,Journal Of General Chemistry Of The Ussr,1984,Vol. 54,# 11,P. 2279-2281 标题:Makhaev,V. D.; Borisov,A. P.,Journal Of General Chemistry Of The Ussr,1984,Vol. 54,# 11,P. 2279-2281
专利号:US-10889599-B2 优先权日:2018-02-27 标 题:1,1-diborylalkyl-1-metal compounds, preparation method thereof, and their applications toward synthesis of 1,1-diboronate ester compounds 发明人:CHO SEUNG HWAN; LEE YEOSAN 权利人:POSTECH ACAD IND FOUND 摘要:The present invention relates to a 1,1-diborylalkyl-1-metal compound including one metal group together with two identical boron groups at the sp3 carbon center, and its use. Specifically, the present invention relates to development of novel organic reactions, synthesis of functional molecules, and synthesis of new drugs by applying the novel 1,1-diboryl-1-metal substituted alkyl compounds to various molecular libraries which could not be synthesized by conventional methodologies.
专利号:WO-2024013633-A1 优先权日:2022-07-11 标 题 :Process for the synthesis of vitamin k2 发明人:SHASTRI MAYANK; BAIKAR MRUNALI H; VORA PARIN K; BNS RAJU 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.
专利号:US-7141702-B2 优先权日:2004-03-26 标 题 :Process for the synthesis of α-substituted acroleins 发明人:DESHPANDE RAJ M; DIWAKAR MAKARAND M; CHAUDHARI RAGHUNATH V 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides an improved process for the synthesis of α-substituted acroleins from olefins by a tandem hydroformylation and Mannich reaction sequence in the presence of syngas and formaldehyde, wherein the two catalysts are segregated into two different phases thereby preventing deactivation of the catalysts by each other, and yielding a highly selective and active catalyst.
专利号:WO-2005063668-A1 优先权日:2003-12-31 标题 :Process for synthesis of alpha-substituted acroleins 发明人:DESHPANDE RAJ MADHUKAR; DIWAKAR MAKARAND MADHUKAR; CHAUDHARI RAGHUNATH VITTHAL 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides an improved process for the synthesis of α-substituted acroleins from olefins by a tandem hydroformylation and Mannich reaction sequence in the presence of syngas and formaldehyde, wherein the two catalysts are segregated into two different phases thereby preventing deactivation of the catalysts by each other, and yielding a highly selective and active catalyst.
专利号:US-9403854-B2 优先权日:2001-03-30 标 题 :Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene complexes as metathesis catalysts 发明人:GRUBBS ROBERT H; CHATTERJEE ARNAB K; CHOI TAE-LIM; GOLDBERG STEVEN D; LOVE JENNIFER A; MORGAN JOHN P; SANDERS DANIEL P; SCHOLL MATTHIAS; TOSTE F DEAN; TRNKA TINA M 权利人:CALIFORNIA INST OF TECHN 摘要:The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.
专利号:US-11718584-B2 优先权日:2019-02-22 标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof 发明人:KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR 权利人:PI INDUSTRIES LTD 摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)
参考文献:10.1021/ol100078w 摘要:Sriramurthy V, Kwon O. Diphosphine-catalyzed mixed double-Michael reaction: a unified synthesis of indolines, dihydropyrrolopyridines, benzimidazolines, tetrahydroquinolines, tetrahydroisoquinolines, dihydrobenzo-1,4-oxazines, and dihydrobenzo-3,1-oxazines. Org Lett. 2010 Mar 05;12(5):1084–7.