CAS: 72824-04-5; 2-Allyl-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane

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69611-02-5 69611-01-4 82954-89-0

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CAS号106-95-6 烯丙基溴 | CAS号25015-63-8 频那醇硼烷 | CAS号107-05-1 氯丙烯 | CAS号73183-34-3 双戊酰二硼 | CAS号339552-93-1 ethyl 3-(4-(all... | CAS号61676-62-8 2-异丙氧基-4,4,5,5-... | CAS号865-47-4 叔丁醇钾 | CAS号76-09-5 频哪醇 | CAS号593-71-5 氯碘甲烷 | CAS号75927-49-0 4,4,5,5-四甲基-2-乙... | CAS号487-11-6 5-烯丙基-1,2,3-三甲氧基苯 | CAS号4743-74-2 2-苯基-4-五亚乙基六胺-2-醇 | CAS号3333-13-9 1-烯丙基-4-甲基苯 | CAS号873-66-5 反-β-甲基苯乙烯 | CAS号98-83-9 α-甲基苯乙烯 | CAS号300-57-2 烯丙基苯 | CAS号92-52-4 联苯 | CAS号3412-44-0 trans-β-benzyls... | CAS号83947-55-1 反式-1-辛烯-1-基硼酸频哪酯 | CAS号74213-47-1 (Z)-4,4,5,5-tet...

频哪醇置于乙二醇二甲醚,Magnesium体系中,20.0~68.0 °C,100.0 Kpa 条件下,反应 5.0H,反应生成 烯丙基硼酸频哪醇酯
参考文献:一种硼化试剂二甲胺基硼酸频哪醇酯,合成及 应用
标题:一种硼化试剂二甲胺基硼酸频哪醇酯,合成及 应用
摘要:本发明涉及一种新型硼化试剂二甲胺基硼酸频哪醇酯pinb(Dma)的结构如下:合成具体步骤为:在50~70oc温度条件下,原料b(Nme2)3与频哪醇在无溶剂条件下反应2~5小时,在-0.1Mpa真空条件下蒸馏,收集45-50oc馏分,即为产品.本发明二甲胺基硼酸频哪醇酯,具有水敏感性低,结构稳定,在参与硼化反应时可避免超低温反应等特性,而具有重要的市场价值.本发明硼化试剂的合成与同类工艺相比具有显著的特点:反应步骤简单,工艺条件温和易操作,无溶剂反应,且工艺稳定性好,易于实现工业化生产,后处理简单,且收率高,纯度好.本发明硼化试剂纯度好,在硼化反应中有着广泛的应用前景.

专利信息

专利号:US-9403854-B2
优先权日:2001-03-30
标 题 :Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene complexes as metathesis catalysts
发明人：GRUBBS ROBERT H; CHATTERJEE ARNAB K; CHOI TAE-LIM; GOLDBERG STEVEN D; LOVE JENNIFER A; MORGAN JOHN P; SANDERS DANIEL P; SCHOLL MATTHIAS; TOSTE F DEAN; TRNKA TINA M
权利人:CALIFORNIA INST OF TECHN
摘要:The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.

专利号:WO-2023086801-A1
优先权日:2021-11-09
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-6191277-B1
优先权日:1998-04-29
标 题:Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases
发明人：DOLLE III ROLAND ELLWOOD; CAVALLARO CULLEN LEE; HERPIN TIMOTHEE FELIX
权利人:PHARMACOPEIA INC
摘要:Compounds of Formula Iare disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathsepsin D. The compounds are useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is a heterocycle, amide, sulfonamide or carbamate and Z is an acyl or a functionalized acyl. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid phase support, are also disclosed.

专利号:US-12435034-B2
优先权日:2020-10-19
标 题 :Process of preparing 3-fluoro-5(((1R,2AR)-3,3,4,4-tetrafluoro-1,2A-dihydroxy-2,2A,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)-oxy)benzonitrile
发明人：FU JIPING; LOU YAN; HE YIGANG; SHI YUETAO; ZHOU PENG; LI XINGXING
权利人:NIKANG THERAPEUTICS INC
摘要:Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:US-2024229131-A1
优先权日:2022-12-22
标 题 :Transition-metal catalyst compositions and methods for sequencing by synthesis
发明人：MARIANI ANGELICA; BEECH TIMOTHY; FRANCAIS ANTOINE; PANIGRAHI ADYASHA; HATTINGH KATHRYN; CRESSINA ELENA
权利人:ILLUMINA INC
摘要:The present application relates to compositions and methods for sequencing by synthesis. A blocking group of a nucleotide may be removed by a transition metal catalyst, the transition metal catalyst activated by a non-reducing ligand and a reducing agent.