CAS: 6945-67-1; 2-Bromo-4-Nitropyridine

相似化合物

7598-35-8 175422-04-5 97944-46-2

上下游产品

CAS号52092-43-0 2-溴-4-硝基吡啶-N-氧化物 | CAS号1124-33-0 4-硝基吡啶-N-氧化物 | CAS号7598-35-8 4-氨基-2-溴吡啶 | CAS号17117-13-4 2-溴-4-乙氧基吡啶

2-溴-4-硝基吡啶氮氧化物置于三溴化磷体系中,用 氯仿 作为反应溶剂,化学反应 1.0H,以92%的收率获得产物2-溴-4-硝基吡啶
参考文献: Pyridyl Substituted Heterocycles Useful For Treating Or Preventing Hcv Infection[fr] Heterocycles A Substitution Pyridyle Utiles Dans Le Traitement De L'Infection Par Le Virus De L'Hepatite C
标题: Pyridyl Substituted Heterocycles Useful For Treating Or Preventing Hcv Infection[fr] Heterocycles A Substitution Pyridyle Utiles Dans Le Traitement De L'Infection Par Le Virus De L'Hepatite C

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CN-115160220-A
优先权日:2022-08-06
标 题 :A kind of synthesis technique of pyridine-N-oxide

专利号:CN-106588915-A
优先权日:2016-10-26
标 题 :Synthesis method of drug precursor for Alzheimer's disease tau protein diagnosis and treatment

专利号:CN-106588915-B
优先权日:2016-10-26
标 题 :Synthesis method of drug precursor for Alzheimer's disease tau protein diagnosis and treatment