CAS: 60-70-8; (2S,3R,5S)-2-((S)-1-((3S,6Ar,11As,11Br)-3-Hydroxy-10,11B-Dimethyl-2,3,4,6,6A,11,11A,11B-Octahydro-1H-Benzo[a]Fluoren-9-yl)Ethyl)-5-Methylpiperidin-3-Ol
该化合物是来自植物基因变异体的藻类,通常被称为假黑桃,其特点是复杂的分子结构,包括多环和功能组,有助于其生物活动; 甲草胺以其药理特性而著称,特别是其作为血管血管的能力及其对心血管系统的潜在影响; 已经研究过其在调节血压方面的作用及其对...
- 英文名称(2S,3R,5S)-2-((S)-1-((3S,6Ar,11As,11Br)-3-Hydroxy-10,11B-Dimethyl-2,3,4,6,6A,11,11A,11B-Octahydro-1H-Benzo[a]Fluoren-9-yl)Ethyl)-5-Methylpiperidin-3-Ol
- 中文名称黎芦碱
- IUPAC名称(2S,3R,5S)-2-((S)-1-((3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-2,3,4,6,6a,11,11a,11b-octahydro-1H-benzo[a]fluoren-9-yl)ethyl)-5-methylpiperidin-3-ol
- 其它别名(2S,3R,5S)-2-((S)-1-((3S,6Ar,11As,11Br)-3-Hydroxy-10,11B-Dimethyl-2,3,4,6,6A,11,11A,11B-Octahydro-1H-Benzo[a]Fluoren-9-yl)Ethyl)-5-Methylpiperidin-3-Ol; (3Beta,23Beta)-14,15,16,17-Tetradehydroveratraman-3,23-Diol
- CAS编号60-70-8
- MFCD编号:MFCD00468124
- EINECS号:683-091-5
- FDA UNII编号:RK363YG315
- 分子式:C27H39NO2
- 分子量:409.61
- 产品CID: 1588056
- 产品分类生物化工 → 提取物 → 植物提取物
- 相似结构搜索
- InChIKey: MALFODICFSIXPO-KFKQDBFTSA-N
- MALFODICFSIXPO-KFKQDBFTSA-N…
- 计算化学: 氢键受体数3.0氢键供体数3.0可旋转键数2.0
物理性质
- 熔点122-124 °C
- 沸点565.0±50.0 °C at 760 mmHg
- 闪点86.2±20.7 °C
- 密度1.1±0.1 g/cm3
- PH:D25 -71.8° (c = 1.21); D25 -70° (c = 1.56 in methanol)
- pKa:14.82±0.60(预测)
- PSA:52.49
- LogP:4.9
- 折射率1.601
- 蒸汽压0.0±1.6 mmHg at 25°C
- 溶解性Soluble In DMSO (Up To 12 mg/mL) Or In Ethanol (Up To 10 mg/mL)
- 外观形态棕褐色固体
- 储存条件密封干燥,冷冻保存, 低于 -20°C
- 产品应用该化合物用作信号传导抑制剂,并具有抗振素活动.
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
急性毒性 类别4(经口)
生殖毒性 类别2
急性毒性 类别2(经口)
急性毒性 类别3(经口) - 警示词Warning(警告)
- 危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H361d |怀疑对胎儿造成损害.
H300 |吞咽致命.
H301 |吞咽会中毒.
H361 |怀疑对生育能力或胎儿造成损害. - 防范说明P501-P270-P264-P301+P310+P330-P405
- 危险等级6.1
- UN编号UN 2811 6.1/PG III
- 包装等级III
- 安全声明H303+H313+H333
- 危险类别码Emergency treatment: Plants- veratrum alkaloids; Excessive amounts can cause death by central respiratory depression; [HSDB] Veratrum alkaloids (e.g., black snakeroot, false hellebore, and skunk cabbage) cause gastroenteritis, bradycardia, paresthesias, AV block, and syncope;; [Olson, p. 376-92]
欧盟法规
C&L通报合成工艺路线路线简述
专利信息
专利号:EP-3137618-A1
优先权日:2014-04-29
标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
专利号:US-2017058305-A1
优先权日:2014-04-29
标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
专利号:US-2021198706-A1
优先权日:2014-04-29
标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
专利号:WO-2015164960-A1
优先权日:2014-04-29
标 题:Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
专利号:CN-105008528-A
优先权日:2012-12-21
标 题 :Engineered biocatalysts and methods for the synthesis of chiral amines
专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof
网址: http://www.aktinchem.com
电话: 86-28-85159085👤
销售电话:86-28-85159085
邮箱：info@aktinchem.com
电话: 86-28-85159085👤
📞成都健腾生物技术有限公司 ⚠️参考联系方式
销售电话:86-28-85159085
邮箱：info@aktinchem.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。第 1 / 1 页
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Zott MD, Zuschlag DW, Trauner DH. Concise Synthesis of (-)-Veratramine and (-)-20-iso-Veratramine via Aromative Diels-Alder Reaction. J Am Chem Soc. 2025 Jan 29;147(4):3010-3016. doi: 10.1021/jacs.4c16495. Epub 2025 Jan 15. 19(12):e0303954. doi: 10.1371/journal.pone.0303954.
3: Menpadi N, Chandra P, Dubey VK. Molecular Mechanisms of Cell Death in Leishmania donovani Induced by Selected Steroidal Alkaloids. J Basic Microbiol. 2025 Mar;65(3):e2400655. doi: 10.1002/jobm.202400655. Epub 2024 Nov 27.
15:1400616. doi: 10.3389/fmicb.2024.1400616.
合成参考文献
摘要:Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-161
摘要:Clarke, M. L., D. G. Harvey and D. J. Humphreys. Veterinary Toxicology. 2nd ed. London: Bailliere Tindall, 1981., p. 240
摘要:The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 1422
参考文献:10.1016/s0022-3565(25)12523-8
摘要:INNES IR, KRAYER O. STUDIES ON VERATRUM ALKALOIDS. XXVII. THE NEGATIVE CHRONOTROPIC ACTION OF VERATRAMINE AND RESERPINE IN THE HEART DEPLETED OF CATECHOL AMINES. The Journal of Pharmacology and Experimental Therapeutics. 1958 Nov;124(3):245–51. doi: 10.1016/s0022-3565(25)12523-8.
摘要:KOSTERLITZ HW, KRAYER O, MATALLANA A. The effect of moderately large doses of veratramine and veratrosine on the rhythm of the acutely denervated heart of the cat. J Physiol. 1954 May 28;124(2):40P.
📝 需求与反馈
尽可能描述清楚需求与问题信息
