CAS: 536-80-1; Iodosylbenzene

上下游产品

iodobenzene (Dichloroiodo)benzene [bis(acetoxy)iodo]benzene iodoxybenzenephenyl-[2]thienyl-iodonium ; chloride [bis-(2,2-dichloroacetyloxy)iodo]benzene diphenyl-iodonium ; hydroxide Phenyl vinyl sulfoxide

📜碘苯二乙酸置于sodium Hydroxide体系中,化学反应 0.08H,反应生成 亚碘酰苯
参考文献:铑(II)催化重氮化合物和苯基碘鎓叶立德分子间和分子内环丙烷化:合成和手性分析.
标题:铑(II)催化重氮化合物和苯基碘鎓叶立德分子间和分子内环丙烷化:合成和手性分析.
摘要:衍生自梅德鲁姆酸(= 2,2-二甲基-1,3-二恶烷-4,6-二酮; 4),丙二酸二甲酯(5),2-重氮-3-(甲硅烷氧基)但是-的不同类别的环丙烷3烯酸酯16,2-重氮基-3,3,3-Trifluoropropanoate 18,重氮(三乙基甲硅烷)乙酸酯24A中,和重氮(二甲基苯基)乙酸甲酯24B的制备通过二铑(II)催化的一组烯烃的分子间环丙烷3(方案1和4-6).该反应用不含重氮的苯基碘化铵或重氮化合物进行,得到外消旋或对映体富集形式的所需环丙烷衍生物.烯丙基重氮(三乙基甲硅烷基)乙酸酯28,30和33的分子内环丙烷化反应是在手性二chi (II)催化剂[rh 2 {((S)-Nttl)4 }](9)的存在下进行的,得到甲苯相应的环丙烷衍生物29,31和34,Ee最高为37%(方案7).建立了一种基于对映选择性gc和HPLC的高效对映选择性手性分离方法.该方法提供了有关环丙烷
DOI:10.1002/hlca.200590003

专利信息

专利号:US-10053406-B2
优先权日:2015-10-23
标题 :Synthesis of honokiol
发明人：JARACZ STANISLAV; KOZLOWSKI MARISA; EUN LEE YOUNG; KIM SUN MIN
权利人:COLGATE PALMOLIVE CO; UNIV PENNSYLVANIA
摘要:Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.

专利号:US-9765083-B2
优先权日:2013-12-03
标 题 :Method for the synthesis of irinotecan
发明人：ZABUDKIN ALEXANDER; MATVIENKO VIKTOR
权利人:SYNBIAS PHARMA AG
摘要:The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. iriniotecan), comprising: (a) preparing 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptotecin; and (b) selectively ethylating the compound of step (a) at the 7-position, thus resulting in the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin. The present invention is further directed to the use of 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. 7-des-ethyl-irinotecan) as intermediate in a method for the synthesis of irinotecan as described.

专利号:US-5859268-A
优先权日:1996-04-09
标 题:Process for the synthesis of α, β-unsaturated esters
发明人：ANGELICI ROBERT J; SHIH KUO-CHEN
权利人:UNIV IOWA STATE RES FOUND INC
摘要:The present invention provides a process for the synthesis of an α,β-unsaturated ester from a mono-olefin-ester using Fe(CO) 5 .

专利号:US-5286901-A
优先权日:1990-03-09
标题:Prescursors for and synthesis of mono- and difunctionalized acetylenes and difunctional 1,3-diynes
发明人：STANG PETER J; CRITTELL CHARLES M; WILLIAMSON BOBBY L; ZHDANKIN VIKTOR
权利人:UNIV UTAH RES FOUND
摘要:Precursors and methods for the synthesis of mono- and difunctionalized acetylenes are described. The invention includes novel tricoordinate iodonium transfer reagents and novel alkynyldi(phenyliodonium) salts, both of which are precursors for the functionalized acetylenes. The iodonium transfer reagents take the general form of mixed iodonium sulfonates PhI + (X)OSO 2 R f , where X may be OAc, NHAc, NCO, or CN. These mixed iodonium sulfonates are produced by reaction of iodosobenzene with certain substituted trimethylsilanes. n To make the alkynyldi(phenyliodonium) salt PhI + C.tbd.CI + Ph•2 R f SO 3 - ,a mixed iodonium sulfonate is reacted with a bistin acetylene of the kind R' 3 SnC.tbd.CSnR' 3 . Alternatively, the reaction may be performed with disubstituted tin diacetylenes to produce PhI + C.tbd.C-C.tbd.CI + Ph•2 R f SO 3 - to produce a dialkynyldi(phenyliodonium) salt. Subsequent reaction of a nucleophile with the alkynyldi(phenyl-iodonium) salt or dialkynyldi(phenyliodonium) salt produces a difunctional acetylene or a difunctional 1,3-diyne, respectively.

专利号:US-8173817-B2
优先权日:2004-05-28
标 题 :Stereoselective synthesis of benzimidazole sulfoxides
发明人：REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA
权利人:REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA; HETERO DRUGS LTD
摘要:The present invention relates to a process for stereoselective synthesis of substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole is reacted with (R)-camphorsulfonyl chloride to form a mixture of 1-(R)-camphorsulfonyl-5- (and 6-)methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1H-benzimidazole, oxidized to obtain a diastereomeric excess of 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole over 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole, the diastereomers are separated by fractional crystallization and the separated 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole is deprotected to give esomeprazole.

专利号:US-10487099-B2
优先权日:2017-06-30
标 题:Synthesis of hypervalent iodine reagents with dioxygen
发明人：POWERS DAVID CHARLES; MAITY ASIM; HYUN SUNG-MIN
权利人:TEXAS A & M UNIV SYS
摘要:Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.