专利号:US-4334079-A 优先权日:1980-11-03 标 题:Synthesis of substituted benzyl esters 发明人:GREENE JAMES M; BUNNELL CHARLES A 权利人:LILLY CO ELI 摘要:A process for preparing certain substituted benzyl esters of phenylacetic acids by esterification in a solvent in which the salt of the acid is insoluble, and in the presence of a phase transfer catalyst.
专利号:US-6753347-B2 优先权日:1999-06-28 标题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof 发明人:KISHI NAOYUKI; NAKAMURA YOSHITAKA; ABE NARUMI; TAKEBAYASHI TOYONORI 权利人:SANKYO CO 摘要:This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, n wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, etc., R 2 is C 1 -C 6 alkyl, and R 3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.
专利号:US-2009023606-A1 优先权日:2004-08-12 标 题:Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof 发明人:GAVELIN PATRIK; PEHR-REHNBERG NICOLA; JOHANNSEN IB 权利人:VERSAMATRIX AS 摘要:The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≧2.
专利号:US-2023192718-A1 优先权日:2018-03-30 标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof 发明人:SANDANAYAKA VINCENT 权利人:NIROGY THERAPEUTICS INC 摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.
专利号:US-2003199580-A1 优先权日:1999-06-28 标 题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof
专利号:WO-0230356-A2 优先权日:2000-10-13 标题:Synthesis of epothilones and relates analogs
摘要:Braun, M., Science of Synthesis Knowledge Updates, (2017) 1, 461. 参考文献:10.1007/bf02976621 摘要:Kim Y, You YJ, Nam NH, Ahn BZ. 2,3-dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity. Arch Pharm Res. 2002 Jun;25(3):240–9. doi: 10.1007/bf02976621.