CAS: 52289-93-7; 1-(Bromomethyl)-2-Methoxybenzene

该化合物是一种该化合物是一种溴代代苯环,其元体位置为甲氧基组,该化合物因其稳定性而备受珍视,适合一系列合成反应,特别是在有机合成和制药应用中.其独特的电子特性使它成为生物活性化合物的制备中有价值的中间体.

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CAS号612-16-8 2-甲氧基苯甲醇 | CAS号578-58-5 邻甲基苯甲醚 | CAS号497-19-8 纯碱 | CAS号135-02-4 邻甲氧基苯甲醛 | CAS号90-02-8 水杨醛 | CAS号42307-45-9 3-(2-甲氧苯基)-2-苯基... | CAS号193546-30-4 (2R)-2-acetamid... | CAS号90-82-4 伪麻黄碱 | CAS号170642-31-6 (R)-2-氨基-3-(2-甲... | CAS号170642-26-9 (R)-2-((叔丁氧基羰基)... | CAS号2553-04-0 2-甲氧基苯甲酮 | CAS号83845-84-5 (2R,3R)-2-(2-me... | CAS号25016-01-7 5-溴-2-甲氧基苯甲醛 | CAS号6342-77-4 3-(2-甲氧基苯基)丙酸 | CAS号6609-56-9 2-甲氧基氰苯

合成工艺路线路线简述

    📜2-甲基苯甲醚置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 作为反应溶剂,化学反应 2.0H,反应生成 2-甲氧基溴苄
    参考文献:无金属条件下甲基芳烃一锅法转化为芳香醛
    标题:无金属条件下甲基芳烃一锅法转化为芳香醛
    摘要:在通过用 N-甲基吗啉 N-氧化物处理将苄基溴转化为相应的芳香醛的研究的基础上,在 Aibn 的存在下,在回流的乙腈中用 Dbdmh 或用 Nbs 处理各种甲基芳烃ccl4置于30 oc 下用钨灯照射(方法 B),然后用 N-甲基吗啉 N-氧化物处理以提供高产率的芳香醛.这些方法可用于在无毒性较小的试剂和过渡金属的条件下将甲基芳烃一锅法转化为芳香醛.
    DOI:10.1002/ejoc.201402015

    海关参考信息

    专利信息


    专利号:US-4334079-A
    优先权日:1980-11-03
    标 题:Synthesis of substituted benzyl esters
    发明人:GREENE JAMES M; BUNNELL CHARLES A
    权利人:LILLY CO ELI
    摘要:A process for preparing certain substituted benzyl esters of phenylacetic acids by esterification in a solvent in which the salt of the acid is insoluble, and in the presence of a phase transfer catalyst.

    专利号:US-6753347-B2
    优先权日:1999-06-28
    标题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof
    发明人:KISHI NAOYUKI; NAKAMURA YOSHITAKA; ABE NARUMI; TAKEBAYASHI TOYONORI
    权利人:SANKYO CO
    摘要:This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, n wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, etc., R 2 is C 1 -C 6 alkyl, and R 3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.

    专利号:US-2009023606-A1
    优先权日:2004-08-12
    标 题:Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof
    发明人:GAVELIN PATRIK; PEHR-REHNBERG NICOLA; JOHANNSEN IB
    权利人:VERSAMATRIX AS
    摘要:The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≧2.

    专利号:US-2023192718-A1
    优先权日:2018-03-30
    标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof
    发明人:SANDANAYAKA VINCENT
    权利人:NIROGY THERAPEUTICS INC
    摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

    专利号:US-2003199580-A1
    优先权日:1999-06-28
    标 题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof

    专利号:WO-0230356-A2
    优先权日:2000-10-13
    标题:Synthesis of epothilones and relates analogs

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Braun, M., Science of Synthesis Knowledge Updates, (2017) 1, 461.
    参考文献:10.1007/bf02976621
    摘要:Kim Y, You YJ, Nam NH, Ahn BZ. 2,3-dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity. Arch Pharm Res. 2002 Jun;25(3):240–9. doi: 10.1007/bf02976621.
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