CAS: 51325-91-8; 2-(2-(4-(Dimethylamino)Styryl)-6-Methyl-4H-Pyran-4-Ylidene)Malononitrile

相似化合物

177086-91-8 28286-88-6 51325-95-2

上下游产品

4-dicyanomethylene-2,6-dimethyl-4H-pyran 4-dimethylamino-benzaldehyde dimethyl amine 4-bromo-benzaldehyde

2,6-二甲基-4H-4-亚吡喃基丙二腈置于copper(L) Iodide,Sodium Methylate,Potassium Carbonate,L-脯氨酸体系中,用 甲醇,二甲基亚砜 作为反应溶剂,化学反应 48.0H,反应生成 4-(二巯基亚甲基)-2-甲基-6-(对二甲氨基苯乙烯基)-4H-吡喃
参考文献:过渡金属催化的溴取代的吡苯二胺衍生物的cn交叉偶联反应:吡喃基生色团的合成,表征和光学性质研究
标题:过渡金属催化的溴取代的吡苯二胺衍生物的cn交叉偶联反应:吡喃基生色团的合成,表征和光学性质研究
摘要:摘要在这项工作中,在过渡金属催化剂的存在下,研究了溴取代的吡苯二胺衍生物与各种仲胺之间的c-n交叉偶联反应.选择cui / L-脯氨酸,Pd(oac)2 / Pph 3和mncl 2 .6H2O / L-脯氨酸作为催化剂/配体体系.在1-脯氨酸作为辅助配体存在下的铜催化的ullmann胺化反应显示出最佳收率.吡喃基发色团的结构已通过ft-Ir,1 H NMR,13确证13 C NMR和质谱.此外,使用uv-Vis和荧光光谱研究了最终化合物的线性光学性质.最终化合物的大斯托克斯位移显示了在光学应用中使用这些化合物的能力. 图形摘要
DOI:10.1007/s13738-020-01956-5

专利信息

专利号:US-2025313590-A1
优先权日:2024-03-16
标题:Phosphoramidite morpholino monomers towards synthesis/convergent synthesis of PMO, TMO, their chimera oligos in 5 prime to 3 prime direction
发明人：SINHA SURAJIT; GHOSH ATANU; BANERJEE ARPAN
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:The present invention relates to 5′-morpholino amidite monomers as 5′-CE/5′- t Bu phosphoramidite morpholino monomers (2) and process chemistry for the efficient synthesis of N-Trityl or monomethoxytrityl (MMTr)-protected 5′-morpholino amidite monomers and their use in the synthesis of phosphorodiamidate morpholino oligonucleotides (PMO), thiophosphoramidate morpholino oligonucleotides (TMO) and their chimeras which can be used for antisense technology or in general oligonucleotides related research.

专利号:US-12012427-B2
优先权日:2019-10-31
标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
发明人：SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.

专利号:US-11236029-B2
优先权日:2019-05-17
标题 :Synthesis of a triangulene ring system and derivatives thereof
发明人：JOHNSON RICHARD PETER; HOLT CARTER J
权利人:THE UNIV OF NEW HAMPSHIRE; UNIV NEW HAMPSHIRE
摘要:A three step synthesis of the 8,12-dihydro-4H-dibenzo[cd,mn]pyren-3a 2 -ylium cation (triangulenium cation) is effected by cascade cyclization of a tetra-benzyl alcohol precursor in triflic acid solution. This cation is easily observed by NMR and optical spectroscopy. Quenching of the cation into basic solutions or by hydride transfer from triethylsilane provides access to stable dihydro and tetrahydro[3]triangulenes. This route makes several [3]triangulene precursors more readily available for development of new applications in the field of molecular electronics.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.