CAS: 4619-20-9; 4-Oxo-4-(P-Tolyl)Butanoic Acid

上下游产品

succinic acid anhydride toluene methyl 4-(4-methylphenyl)-4-oxobutanoate 4-(Dimethylhydrazono)-1-(4-methylphenyl)-2-buten-1-on methyl 4-(4-methylphenyl)-4-oxobutanoate E)-5,5'-di-p-tolyl-[3,3']bifurylidene-2,2'-dione(E)-5,5'-di-p-tolyl-[3,3']bifurylidene-2,2'-dione ethyl 4-oxo-4-(p-tolyl)butanoate 5-(4-methylphenyl)-3H-furan-2-one

4-(Dimethylhydrazono)-1-(4-Methylphenyl)-2-Buten-1-On置于盐酸,聚合甲醛体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 3-(4-甲基苯甲酰)丙酸
参考文献:Severin,T.; Poehlmann,H.,Chemische Berichte,1978,Vol. 111,P. 1564-1577
标题:Severin,T.; Poehlmann,H.,Chemische Berichte,1978,Vol. 111,P. 1564-1577

专利信息

专利号:US-6921839-B2
优先权日:2000-08-29
标 题:Synthesis of N,N-dimethyl-3-(4-methyl) benzoyl propionamide a key intermediate of zolpidem
发明人：KUMAR YATENDRA; PRASAD MOHAN; NATH ASOK
权利人:RANBAXY LAB LTD
摘要:The present invention relates to an improved and industrially advantageous process for the preparation of N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula I, n n nwhich is a key intermediate in the synthesis of zolpidem hemitartrate, a non-benzodiazepine hypnotic agent. The process includes reacting 3-(4-methyl)-benzoyl propionic acid of Formula IV, with alkyl chloroformate or pivaloyl chloride to get a mixed anhydride of Formula V; and reacting the mixed anhydride of Formula V with dimethylamine of Formula VI to get the N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula I.

专利号:EP-1370515-A2
优先权日:2000-08-29
标题:Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem

专利号:US-2004054230-A1
优先权日:2000-08-29
标 题 :Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide a key intermediate of zolpidem

专利号:WO-0218303-A2
优先权日:2000-08-29
标 题 :Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem