CAS: 269055-75-6; 4-((5-Bromo-4,6-Dichloropyrimidin-2-yl)Amino)Benzonitrile

该化合物是一种卤化的激素衍生物,可能用于制药和农用化学研究,其结构具有溴和二氯替代品的火利米丁核心,通过氨基桥与苯共基相连,为进一步功能化提供了多功能性.该化合物的电镀组增强了其再活性,使它成为七环合成中有价值的中间体.其明确界定的卤化模式允许有选择性的交叉反应,便利新生物活性分子的开发.苯三烯组有助于溶性和结合性,扩大其在药用化学中的效用.该化合物特别适合于对动脉抑制和农药开发的探索性研究,因为其坚固的树脂结.

英文名称4-((5-Bromo-4,6-Dichloropyrimidin-2-yl)Amino)Benzonitrile
中文名称4-((5-溴-4,6-二氯嘧啶-2-基)氨基)苯甲腈
IUPAC名称4-((5-bromo-4,6-dichloropyrimidin-2-yl)amino)benzonitrile
其它别名4-[(5-溴-4,6-二氯-2-嘧啶)氨基]苯甲腈; 4-[(5-Bromo-4,6-Dichloropyrimidin-2-yl)Amino]Benzonitrile
CAS编号269055-75-6
MFCD编号:MFCD11865109
分子式:C11H5BrCl2N4
分子量:344.0
产品CID: 1248526
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: IGZKXTGKGMPSTG-UHFFFAOYSA-N
InChI=1S/C11H5BrCl2N4/c12-8-9(13)17-11(18-10(8)14)16-7-3-1-6(5-15)2-4-7/h1-4H,(H,16,17,18)…
计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数2.0

相似化合物

244768-32-9 1398507-08-8 950752-52-0

MSDS等安全信息

上下游产品

CAS号128-08-5 N-溴代丁二酰亚胺 | CAS号329187-59-9 4-N[2(4,6-二氯吡啶基... | CAS号374067-80-8 4-[(4,6-二羟基-2-嘧... | CAS号269055-76-7 6-脱氨基-6-氯四维碱-13C3 | CAS号269055-15-4 依曲韦林

合成工艺路线路线简述

4-N[2(4,6-二氯吡啶基)]-氨基苯腈置于溴,碳酸氢钠体系中,用甲醇,水用作溶剂,以78%的收率获得4-[(5-溴-4,6-二氯-2-嘧啶)氨基]苯甲腈
参考文献:抗艾滋病毒候选药物的演变.第3部分:二芳基嘧啶(dapy)类似物.
标题:抗艾滋病毒候选药物的演变.第3部分:二芳基嘧啶(dapy)类似物.
摘要:描述了一系列二芳基嘧啶(dapys)的合成和抗hiv-1活性.这种新型的非核苷类逆转录酶抑制剂(nnrtis)的几个成员对野生型以及一组具有临床意义的hiv-1单突变和双突变菌株均具有极强的抵抗力.
Doi:10.1016/s0960-894X(01)00412-7

海关参考信息

2902300000-甲苯
2926909090-其他腈基化合物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2015336900-A1
优先权日:2012-10-29
标题 :Process for the Synthesis of Etravirine and Its Intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The invention discloses the synthesis of Etravirine via intermediate 4-((4-amino-5-bromo-6-chloropyrimidin-2-yl) amino)benzonitrile and process for the preparation of Etravirine of the formula-I.

专利号:US-2013123498-A1
优先权日:2011-10-19
标题 :Process for the preparation of etravirine and intermediates in the synthesis thereof
发明人：MAJER MAJA SEPELJ; KRIZMANIC IRENA; VRBANEC GORDANA
权利人:MAJER MAJA SEPELJ; KRIZMANIC IRENA; VRBANEC GORDANA
摘要:The present invention includes compounds of Formula 1 of the following structure: n n n n n n n n n n or salts thereof, wherein X is a halogen or a tosyl group. Processes for preparing the compounds of Formula 1 are disclosed in the patent application. The compounds of Formula 1 are useful as intermediates for preparation of Etravirine. The present invention is also directed toward processes for preparing Etravirine.

专利号:US-2011196156-A1
优先权日:2009-06-22
标题 :Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor

专利号:WO-2010150279-A2
优先权日:2009-06-22
标题 :Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor

专利号:EP-2342186-B1
优先权日:2009-06-22
标题:Process for synthesis of etravirine
发明人：GURJAR MUKUND KESHAV; MAIKAP GOLAKCHANDRA SUDARSHAN; JOSHI SHASHIKANT GANGARAM; PARDESHI DEVISING RAMESHSING; KAMBLE MANGESH GORAKHANATH; MEHTA SAMIT SATISH
权利人:EMCURE PHARMACEUTICALS LTD

专利号:EP-2342186-A2
优先权日:2009-06-22
标题 :Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor