CAS: 176548-70-2; 3-Bromo-5-Fluorobenzoic Acid

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CAS号179898-34-1 3-溴-5-氟苯腈 | CAS号124-38-9 二氧化碳 | CAS号1435-51-4 1,3-二溴-5-氟苯 | CAS号872545-52-3 (2-bromo-6-fluo... | CAS号1073-06-9 间溴氟苯 | CAS号105515-20-6 3-溴-5-氟苯乙酮 | CAS号334792-52-8 3-溴-5-氟苯甲酸甲酯 | CAS号353743-43-8 Ethyl 3-bromo-5... | CAS号216755-56-5 3-溴-5-氟苄醇 | CAS号216755-57-6 3-氟-5-溴溴苄 | CAS号179898-34-1 3-溴-5-氟苯腈 | CAS号1214352-53-0 3',5-DIFLUORO-[... | CAS号887266-90-2 3-溴-5-氟苯甲酰氯 | CAS号933585-20-7 3-溴-5-氟苯甲酰胺

3-溴-5-氟苯腈置于水,Sodium Hydroxide体系中,化学反应 2.0H,以94%的收率获得3-溴-5-氟苯甲酸
参考文献:Discovery And Characterization Of Azd9272 And Azd6538-two Novel Mglur5 Negative Allosteric Modulators Selected For Clinical Development
标题:Discovery And Characterization Of Azd9272 And Azd6538-two Novel Mglur5 Negative Allosteric Modulators Selected For Clinical Development
摘要:Azd9272 And Azd6538 Are Two Novel Mglur5 Negative Allosteric Modulators Selected For Further Clinical Development. An Initial High-Throughput Screening Revealed Leads With Promising Profiles,Which Were Further Optimized By Minor,Yet Indispensable,Structural Modifications To Bring Forth These Drug Candidates. Advantageously,Both Compounds May Be Synthesized In As Little As One Step. Both Are Highly Potent And Selective For The Human As Well As The Rat Mglur5 Where They Interact At The Same Binding Site Than Mpep. They Are Orally Available,Allow For Long Interval Administration Due To A High Metabolic Stability And Long Half-Lives In Rats And Permeate The Blood Brain Barrier To A High Extent. Azd9272 Has Progressed Into Phase I Clinical Studies. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2012.08.100