专利号:US-2022370393-A1 优先权日:2019-10-16 标 题 :Method and composition for increasing muscle protein synthesis 发明人:BELLAMINE AOUATEF; GLAB STANISLAW; DURKEE SHANE 权利人:CAPSUGEL BELGIUM NV 摘要:A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid derivative including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in an acid resistant capsule delivery form. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.
专利号:US-2022370392-A1 优先权日:2019-10-16 标 题:Method and Composition for Increasing Muscle Protein Synthesis 发明人:BELLAMINE AOUATEF; GLAB STANISLAW; DURKEE SHANE 权利人:BELLAMINE AOUATEF; CAPSUGEL BELGIUM NV 摘要:A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid component including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in a solution with L-carnitine. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building z composition can be administered in a monolithic enteric capsule.
专利号:US-10888571-B2 优先权日:2015-12-18 标 题:Method and composition for increasing muscle protein synthesis and/or functional strength in mammals 发明人:BELLAMINE AOUATEF; ZHIVKOVICH ILYA; FREITAS ULLA 权利人:LONZA CONSUMER HEALTH INC 摘要:A method and composition for preserving muscle mass and function by increasing muscle protein synthesis and/or decreasing muscle protein degradation in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at least two of an essential amino acid, an amino acid derivative, and a nitrogenous organic acid. In a particular embodiment, the protein building composition comprises leucine, L-carnitine, and creatine. The protein building composition can decrease TNF-α and increase mTOR expression in muscle.
专利号:US-11970435-B2 优先权日:2017-05-12 标题:Taste-modified creatine salts, compounds, compositions and uses thereof 发明人:LEBEDYEVA IRYNA; KLUG CHRISTOPHER 权利人:UNIV RES INST INC AUGUSTA 摘要:Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily dissolve in water and buffer solutions. Synthesis of novel creatine salts using environmentally safe solvents such as ethanol resulted in the formation of products in quantitative yields with sodium or potassium chloride as a byproduct. The creatine and creatine alkyl eater derivative salts are stable sweet-tasting compounds that are more palatable to a consumer than creatine or derivatives thereof.
专利号:CN-108929249-A 优先权日:2018-09-07 标题:A new synthesis process of creatine ethyl ester hydrochloride
专利号:EP-3389385-A1 优先权日:2015-12-18 标题:Method and composition for increasing muscle protein synthesis and/or functional strength in mammals as well as method of producing a composition
参考文献:10.1186/1550-2783-12-s1-p49 摘要:Jagim A, Wright G, Schultz K, St Antoine C, Jones M, Oliver JM. Effects of acute ingestion of a multi-ingredient pre-workout supplement on lower body power and anaerobic sprint performance. Journal of the International Society of Sports Nutrition. 2015 Sep 21;12(sup1). doi: 10.1186/1550-2783-12-s1-p49. 参考文献:10.1007/s11332-024-01250-4 摘要:Eghbali E, Riahy S, Arazi H. Creatine hydrochloride or creatine monohydrate plus resistance training: which combination has a greater effect on oxidative stress, muscle damage, performance, and body composition in soldiers Sport Sci Health. 2024 Aug 27;21(1):225–38. doi: 10.1007/s11332-024-01250-4. 参考文献:10.1007/s11332-026-01660-6 摘要:Ramezanzadeh M, Arazi H, Saidie P. Acute influence of mixed creatine hydrochloride and caffeine supplementation on serum levels of testosterone and cortisol, repetition sustainability and resistance exercise volume. Sport Sci Health. 2026 Feb 04;22(1). doi: 10.1007/s11332-026-01660-6.