CAS: 1679-47-6; 3-Methyldihydrofuran-2(3H)-One

相似化合物

1679-49-8 4100-80-5 3709-08-8

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A-乙酰-A-甲基-γ-丁内酯置于sodium Ethanolate体系中,用 乙醇 用作溶剂,化学反应 5.0H,以89%的收率获得α-甲基-γ-丁内酯
参考文献:一种新的2 H-Azirin-3-胺作为2-甲基天冬氨酸的合成子
标题:一种新的2 H-Azirin-3-胺作为2-甲基天冬氨酸的合成子
摘要:描述了新型的2,2-二取代的2 H-叠氮基-3-胺3A的合成,作为外消旋asp(2Me)的结构单元.该合成子在侧链中包含酯基.的反应3A与硫代苯甲酸和氨基酸z-Val-Oh产生外消旋monothiodiamide 10A和二肽11作为非对映体,分别为(的混合物反应路线2).在11中,选择性地除去了每个保护基(方案3).描述了制备侧链中具有手性辅助基团的asp(2Me)对映体纯合成子的首次尝试.Synthons 3B制备具有1-(萘-1-基)乙基酯基和具有薄荷基基团的3C,并且使其与硫代苯甲酸反应以形成单硫代二酰胺10B和10C(方案2).然而,合成子3B和3C的非对映异构体不能通过色谱法分离.
Doi:10.1002/hlca.200590238

专利信息

专利号:US-8598346-B2
优先权日:2008-07-16
标 题 :Synthesis of cyclic amidines
发明人：LENTZEN GEORG; NEUHAUS THORSTEN
权利人:LENTZEN GEORG; NEUHAUS THORSTEN; BITOP AG
摘要:The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a β-, γ- or δ-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.

专利号:US-5087703-A
优先权日:1988-01-28
标题 :Process for synthesis of FK-506 intermediates
发明人：VOLANTE RALPH P; ASKIN DAVID; SHINKAI ICHIRO; RYAN KENNETH M
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of diastereomeric 2-methyl-4-hydroxy-5-protected-hydroxy-hept-6-en-prolinolamides, which are useful as intermediates in the synthesis of the C10-C18 chain of the macrolide structure for the immunosuppressant FK-506. These compounds are also useful as intermediates for preparing lactone ultraviolet radiation absorbers.

专利号:US-6770763-B2
优先权日:2002-06-11
标题 :Asymmetric synthesis of amino-pyrrolidinones
发明人：MAGNUS NICHOLAS A; CONFALONE PASQUALE N; SAVAGE SCOTT A; YATES MATTHEW; WALTERMIRE ROBERT E; MELONI DAVID J; CAMPAGNA SILVIO
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below from appropriate pyrrolidinones is described.These compounds are useful as intermediates for MMP and TACE inhibitors.

专利号:WO-03018540-A1
优先权日:2001-08-22
标 题:Synthesis of unsaturated nitriles from lactones
发明人：MANZER LEO E
权利人:DU PONT; MANZER LEO E
摘要:The synthesis of unsaturated nitriles from lactones and ammonia is described using a heterogeneous base catalyst.

专利号:US-11629223-B2
优先权日:2018-01-11
标 题:Synthesis of polymers from cyclic diolides
发明人：CHEN EUGENE Y; TANG XIAOYAN
权利人:UNIV COLORADO STATE RES FOUND
摘要:Biodegradable polymers with advantageous physical and chemical properties are described, as well as methods for making such polymers. In one embodiment, a new chemical synthesis route to technologically important biodegradable poly(3-hydroxybutyrate) (P3HB) with high isotacticity and molecular weight required for a practical use is described. The new route can utilize racemic eight-membered cyclic diolide (rac-DL), meso-DL, or a rac-DL and meso-DL mixture, derived from bio-sourced dimethyl succinate, and enantiomeric (R,R)-DL and (S,S)-DL, optically resolved by metal-based catalysts. With a stereoselective racemic molecular catalyst, the ROP of rac-DL under ambient conditions produces rapidly P3HB with essentially perfect isotacticity ([mm]>99%), high crystallinity and melting temperature (T m =171° C.), as well as high molecular weight and low dispersity (M n =1.54×10 5 g/mol, Ã?=1.01).

专利号:US-2024425890-A1
优先权日:2022-02-11
标 题:Process for the synthesis of alpha-methylene-gamma-butyrolactone
发明人：TADEN ANDREAS; BECK HORST; MYRTOLLARI KAMELA; KOURIST ROBERT; NIGL ANDREA
权利人:HENKEL AG & CO KGAA
摘要:The present application provides a process for the preparation of α-methylene-γ-butyrolactone, said process comprising the steps of:a) acetylating the C1-hydroxyl group of isoprenol to yield isoprenyl acetate;b) forming 4-acetoxy-2-methylene-butan-1-ol from said isoprenyl acetate by whole cell biotransformation, said step comprising:i) contacting a cell (CB) with a culture medium containing said isoprenyl acetate or with a culture medium contiguous with an organic phase containing said isoprenyl acetate under conditions that enable the cell to form 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate; and,ii) optionally isolating the resultant 4-acetoxy-2-methylene-butan-1-ol, wherein said cell (CB) exhibits activity of at least one alkane monooxygenase enzyme which catalyzes the formation of 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate;c) oxidizing said 4-acetoxy-2-methylene-butan-1-ol to yield 4-acetoxy-2-methylene butyric acid; and,d) converting said 4-acetoxy-2-methylene butyric acid to α-methylene-γ-butyrolactone by hydroxylysis to γ-hydroxy-α-methylenebutyric acid and subsequent cyclization of said γ-hydroxy-α-methylenebutyric acid.