CAS: 1646-53-3; 3-Bromo-1,2,4,5-Tetramethylbenzene

相似化合物

1646-54-4 5153-40-2 5469-19-2

上下游产品

CAS号95-93-2 1,2,4,5-四甲苯 | CAS号527-35-5 2,3,5,6-四甲基苯酚 | CAS号5153-40-2 溴五甲基苯 | CAS号22524-51-2 Benzoic acid,2,... | CAS号87-85-4 六甲基苯 | CAS号635-10-9 1,2,4,5-四甲酸四苯甲酯 | CAS号700-12-9 五甲基苯 | CAS号2604-45-7 2,3,5,6-四甲基苯甲酸 | CAS号3360-65-4 1,2,4,5-tetrame... | CAS号3438-34-4 Benzene,1-bromo...

📜1,2,4,5-四甲苯置于sodium Nitrate,氧气,溶剂黄146,三氟乙酸,Sodium Bromide体系中,用88 %的收率获得1-溴-2,3,5,6-四甲基苯
参考文献:亚硝鎓离子催化芳烃氧化溴化
标题:亚硝鎓离子催化芳烃氧化溴化
摘要:已经开发出一种亚硝鎓催化的富电子芳烃溴化方法,使用溴化物盐作为溴源,氧气作为终端氧化剂和布朗斯台德酸(硫酸,Tfa或hbr).该芳烃溴化工艺不含过渡金属,在乙酸和温和温度(25-50 oc)下进行,以非常好至优异的收率获得溴化芳烃.我们的机理研究表明,芳烃的氧化溴化反应是由亚硝鎓离子 (No+) 催化的,没有 Br2 或 Br+ 的参与.使用五氘代苯基苯基醚(kh/kd = 1.1)测量该反应的动力学同位素效应.
Doi:10.1002/adsc.202301200

专利信息

专利号:US-6355826-B1
优先权日:1997-09-17
标题:Synthesis of stable nitrile oxide compounds
发明人：PARKER DANE KENTON
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.

专利号:CA-2245780-A1
优先权日:1997-09-17
标 题 :Synthesis of stable nitrile oxide compounds

专利号:KR-19990029856-A
优先权日:1997-09-17
标 题 :Synthesis of Stable Nitrile Oxide Compounds

专利号:EP-0903338-A2
优先权日:1997-09-17
标 题:Synthesis of stable nitrile oxide compounds

专利号:WO-9743289-A1
优先权日:1996-05-17
标 题 :Large synthetic compounds based on electron donor and electron acceptor interactions
发明人：IVERSON BRENT L; LOKEY R SCOTT
权利人:UNIV TEXAS; IVERSON BRENT L; LOKEY R SCOTT
摘要:Using predetermined electron donor-electron acceptor interactions, the present invention provides for the design, synthesis and use of compounds that are capable of interacting with, competing with and even mimicking biological macromolecules. The compounds may be related structurally and/or functionally to a wide variety of biologicals including proteins, nucleic acids, lipids, carbohydrates, steroids or other compounds. In one embodiment, alternating electron donor-acceptor molecules (AEDAMers) are employed to create compounds having higher order structures including helices and pleats. These compounds may be used in a myriad of different applications, which include roles as inert carriers, antigens, biologically inactive stabilizers, drugs and enzymes. Also contemplated are combinatorial processes for creating large libraries permitting rapid screening for desired structure and/or function.